ID   EF4L2_ARATH             Reviewed;         119 AA.
AC   Q94BS8; Q9CAH8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Protein ELF4-LIKE 2;
GN   Name=EFL2; Synonyms=ELF4-L2; OrderedLocusNames=At1g72630;
GN   ORFNames=F28P22.18;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY.
RX   PubMed=14605220; DOI=10.1104/pp.103.030007;
RA   Khanna R., Kikis E.A., Quail P.H.;
RT   "EARLY FLOWERING 4 functions in phytochrome B-regulated seedling de-
RT   etiolation.";
RL   Plant Physiol. 133:1530-1538(2003).
RN   [6]
RP   INDUCTION BY LIGHT, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=20357892; DOI=10.2976/1.3218766;
RA   Kolmos E., Nowak M., Werner M., Fischer K., Schwarz G., Mathews S.,
RA   Schoof H., Nagy F., Bujnicki J.M., Davis S.J.;
RT   "Integrating ELF4 into the circadian system through combined structural and
RT   functional studies.";
RL   HFSP J. 3:350-366(2009).
CC   -!- FUNCTION: Component of the central CCA1/LHY-TOC1 feedback loop in the
CC       circadian clock that promotes clock accuracy and is required for
CC       sustained rhythms in the absence of daily light/dark cycles.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- INDUCTION: Follows a light-dependent circadian-regulated expression
CC       with a peak at midday, about 6 hours after dawn.
CC       {ECO:0000269|PubMed:20357892}.
CC   -!- SIMILARITY: Belongs to the EARLY FLOWERING 4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG51839.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAM63128.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC010926; AAG51839.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002684; AEE35350.1; -; Genomic_DNA.
DR   EMBL; AY039916; AAK64020.1; -; mRNA.
DR   EMBL; AY079311; AAL85042.1; -; mRNA.
DR   EMBL; AY085916; AAM63128.1; ALT_INIT; mRNA.
DR   PIR; H96750; H96750.
DR   RefSeq; NP_565044.1; NM_105922.4.
DR   AlphaFoldDB; Q94BS8; -.
DR   SMR; Q94BS8; -.
DR   BioGRID; 28814; 2.
DR   IntAct; Q94BS8; 1.
DR   STRING; 3702.AT1G72630.1; -.
DR   iPTMnet; Q94BS8; -.
DR   PaxDb; Q94BS8; -.
DR   PRIDE; Q94BS8; -.
DR   ProteomicsDB; 224743; -.
DR   EnsemblPlants; AT1G72630.1; AT1G72630.1; AT1G72630.
DR   GeneID; 843595; -.
DR   Gramene; AT1G72630.1; AT1G72630.1; AT1G72630.
DR   KEGG; ath:AT1G72630; -.
DR   Araport; AT1G72630; -.
DR   TAIR; locus:2030165; AT1G72630.
DR   eggNOG; ENOG502R34Z; Eukaryota.
DR   HOGENOM; CLU_119738_1_0_1; -.
DR   InParanoid; Q94BS8; -.
DR   OMA; NEVNQNH; -.
DR   OrthoDB; 1495071at2759; -.
DR   PhylomeDB; Q94BS8; -.
DR   PRO; PR:Q94BS8; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q94BS8; baseline and differential.
DR   Genevisible; Q94BS8; AT.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0009649; P:entrainment of circadian clock; IBA:GO_Central.
DR   GO; GO:0009648; P:photoperiodism; IEP:UniProtKB.
DR   GO; GO:0042753; P:positive regulation of circadian rhythm; IEA:InterPro.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   InterPro; IPR040462; EARLY_FLOWERING_4.
DR   InterPro; IPR009741; EARLY_FLOWERING_4_dom.
DR   PANTHER; PTHR33469; PTHR33469; 1.
DR   Pfam; PF07011; Elf4; 1.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Nucleus; Reference proteome.
FT   CHAIN           1..119
FT                   /note="Protein ELF4-LIKE 2"
FT                   /id="PRO_0000408504"
FT   REGION          91..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   119 AA;  13409 MW;  2BB64ACD3C7204F0 CRC64;
     MESRMEGDVY SGFGERYQMD GKLLQNFQKS FVQVQDILDQ NRLLINEINQ NHESKQADHL
     GRNVGLIREL NNNIRTVASL YGDLSHSFAR SVDASSEGES TGTLKSDGKA NNQKRFRSG