ID   EF4L4_ARATH             Reviewed;         114 AA.
AC   Q570U6; Q8LEX9; Q9LDC8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein ELF4-LIKE 4;
GN   Name=EFL4; Synonyms=ELF4-L4; OrderedLocusNames=At1g17455;
GN   ORFNames=F1L3.15, F28G4.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY.
RX   PubMed=14605220; DOI=10.1104/pp.103.030007;
RA   Khanna R., Kikis E.A., Quail P.H.;
RT   "EARLY FLOWERING 4 functions in phytochrome B-regulated seedling de-
RT   etiolation.";
RL   Plant Physiol. 133:1530-1538(2003).
RN   [7]
RP   INDUCTION BY LIGHT, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=20357892; DOI=10.2976/1.3218766;
RA   Kolmos E., Nowak M., Werner M., Fischer K., Schwarz G., Mathews S.,
RA   Schoof H., Nagy F., Bujnicki J.M., Davis S.J.;
RT   "Integrating ELF4 into the circadian system through combined structural and
RT   functional studies.";
RL   HFSP J. 3:350-366(2009).
CC   -!- FUNCTION: Component of the central CCA1/LHY-TOC1 feedback loop in the
CC       circadian clock that promotes clock accuracy and is required for
CC       sustained rhythms in the absence of daily light/dark cycles.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- INDUCTION: Follows a light-dependent circadian-regulated expression
CC       with a small peak in the evening, about 12 hours after dawn.
CC       {ECO:0000269|PubMed:20357892}.
CC   -!- SIMILARITY: Belongs to the EARLY FLOWERING 4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF79463.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAF97300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC007843; AAF97300.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC022492; AAF79463.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE29591.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE29592.1; -; Genomic_DNA.
DR   EMBL; AK220611; BAD94981.1; -; mRNA.
DR   EMBL; BT025588; ABF59006.1; -; mRNA.
DR   EMBL; AY085165; AAM61718.1; -; mRNA.
DR   RefSeq; NP_001154348.1; NM_001160876.1.
DR   RefSeq; NP_564024.1; NM_101607.4.
DR   AlphaFoldDB; Q570U6; -.
DR   SMR; Q570U6; -.
DR   BioGRID; 23558; 1.
DR   STRING; 3702.AT1G17455.1; -.
DR   PaxDb; Q570U6; -.
DR   PRIDE; Q570U6; -.
DR   ProteomicsDB; 247080; -.
DR   EnsemblPlants; AT1G17455.1; AT1G17455.1; AT1G17455.
DR   EnsemblPlants; AT1G17455.2; AT1G17455.2; AT1G17455.
DR   GeneID; 838318; -.
DR   Gramene; AT1G17455.1; AT1G17455.1; AT1G17455.
DR   Gramene; AT1G17455.2; AT1G17455.2; AT1G17455.
DR   KEGG; ath:AT1G17455; -.
DR   Araport; AT1G17455; -.
DR   TAIR; locus:505006126; AT1G17455.
DR   eggNOG; ENOG502R34Z; Eukaryota.
DR   HOGENOM; CLU_119738_1_0_1; -.
DR   InParanoid; Q570U6; -.
DR   OMA; NNANQSD; -.
DR   OrthoDB; 1495071at2759; -.
DR   PhylomeDB; Q570U6; -.
DR   PRO; PR:Q570U6; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q570U6; baseline and differential.
DR   Genevisible; Q570U6; AT.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0009649; P:entrainment of circadian clock; IBA:GO_Central.
DR   GO; GO:0009648; P:photoperiodism; IEP:UniProtKB.
DR   GO; GO:0042753; P:positive regulation of circadian rhythm; IEA:InterPro.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   InterPro; IPR040462; EARLY_FLOWERING_4.
DR   InterPro; IPR009741; EARLY_FLOWERING_4_dom.
DR   PANTHER; PTHR33469; PTHR33469; 1.
DR   Pfam; PF07011; Elf4; 1.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Nucleus; Reference proteome.
FT   CHAIN           1..114
FT                   /note="Protein ELF4-LIKE 4"
FT                   /id="PRO_0000408506"
FT   REGION          87..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   114 AA;  12663 MW;  5B587C1C34AF8DCA CRC64;
     MEGDVLSGFG DRHNMDGKLL QSFQKSFVDV QDILDQNRLL INEINQNHES KQPDNLGRNV
     GLIKELNNNI RRVASLYGDL SHSFARSVDA SSEGESSGTL KSDGKANQKR FRSG