ID   EFC12_MACFA             Reviewed;         569 AA.
AC   Q95LL8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 12;
GN   Name=EFCAB12; ORFNames=QtsA-20224;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
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DR   EMBL; AB072770; BAB69739.1; -; mRNA.
DR   RefSeq; NP_001271567.1; NM_001284638.1.
DR   AlphaFoldDB; Q95LL8; -.
DR   SMR; Q95LL8; -.
DR   STRING; 9541.XP_005571784.1; -.
DR   GeneID; 102131102; -.
DR   CTD; 90288; -.
DR   eggNOG; ENOG502QSZS; Eukaryota.
DR   OrthoDB; 1312266at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR042847; EFC12.
DR   PANTHER; PTHR47225; PTHR47225; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Metal-binding; Reference proteome.
FT   CHAIN           1..569
FT                   /note="EF-hand calcium-binding domain-containing protein
FT                   12"
FT                   /id="PRO_0000238661"
FT   DOMAIN          193..228
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          63..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         210
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000305"
FT   BINDING         212
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000305"
FT   BINDING         217
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   569 AA;  66395 MW;  BA539D941FED9865 CRC64;
     MDDDYEAYHS LFLSLLGLCP SKTSIDENAA VFDPELVIAH CFKQFKQKDF RLPQTRRRII
     MVPRKEDQTP INPASQPQAP PEPIPSFKAL EAKDIQEQPE DRKTWLSRRA KLRQELESFG
     DVKRWLENKP SITPSEAKVL HMIHEEQSAQ TNASQATTRT TRKKGPRLSR QMVPQLQLPK
     PPALSVMYSY LHSRKIKILE IFHKVGQGEN QRITREEFIT AVKAVGVPLK NQEVEDIVIY
     LSSLGKHNTI TMDILANTYK QWSMAQQRSS LATARKRYIL VKHRDSLKGP LKKQEVDAAP
     QLPKVDLLTV PAVDTQMEAR PMTLEEMEEV GKRYRERQRQ HKLMIPSIQY TEQCRLVRCG
     NRHFDEHCLP STIHGDMREL IDSTRRHNFL VYLQCWKLCE SYGLPLTEDI LMKALLYPGD
     KIIFQMDKVR PIRQPGGYYS DWKVFSPNLA LLRSQGPSKS KRTDKKPPKK SKKMHFKEFE
     EFTRKLKVRR SSSLQQTHPN SFWPGHLLDK LQLYLPTVAT DRSLALFSCV QHQPHVYPAT
     YHPDHWWPLR NKNYMTRAYY DAAKVYYIN