ID   EFC4A_DANRE             Reviewed;         390 AA.
AC   A1A600;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 4A;
DE   AltName: Full=Calcium release-activated channel regulator 2B;
GN   Name=cracr2b; Synonyms=efcab4a; ORFNames=zgc:158448;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the EFCAB4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI28878.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC128877; AAI28878.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001073550.1; NM_001080081.1.
DR   AlphaFoldDB; A1A600; -.
DR   SMR; A1A600; -.
DR   STRING; 7955.ENSDARP00000070145; -.
DR   PaxDb; A1A600; -.
DR   PRIDE; A1A600; -.
DR   GeneID; 790936; -.
DR   KEGG; dre:790936; -.
DR   CTD; 283229; -.
DR   ZFIN; ZDB-GENE-061215-136; cracr2b.
DR   eggNOG; ENOG502QRXK; Eukaryota.
DR   InParanoid; A1A600; -.
DR   OrthoDB; 1184845at2759; -.
DR   PhylomeDB; A1A600; -.
DR   PRO; PR:A1A600; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0002115; P:store-operated calcium entry; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Coiled coil; Metal-binding; Reference proteome; Repeat.
FT   CHAIN           1..390
FT                   /note="EF-hand calcium-binding domain-containing protein
FT                   4A"
FT                   /id="PRO_0000395807"
FT   DOMAIN          33..66
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          67..102
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          173..357
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         80
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         82
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         84
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         86
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         91
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   390 AA;  45747 MW;  8CAFEF26F839A9B7 CRC64;
     MSPRSTLRSP LPSRTARSSA SSDTPSPGAD RQDRMSKAKE LFVLCDKEGK GFITKRDMQR
     LQQELPLSPE QLESVFESLD RDRNGYLTPL EFHTGLGELV GSGPEEKVRS AGEIVGEERE
     EPTEIRFTQI LMELGADKLF KDQWELCGLW CELQRDKPEL LGVLEEVLSY TVSHLQDALK
     EKDNLEHALR RREEDHDRVV RSMYEDMESQ LKEERERRQA LDSMRQGDKK EQLLHELRTR
     EQELEFTLTK QRELESRINS LSSDQADARG ENRRLQNVNQ QLQDQLEQSR EELQNSLSQL
     QQLQNTIKLQ QRGKEREVLK VSRNMQKERE SLVRQLELLR DMNKRLRDDK DAHQAQKMVS
     QKHSFTPPTY YPACRCVHNF SPWPRSIYPY