ID   EFC4A_MOUSE             Reviewed;         394 AA.
AC   Q80ZJ8; Q4KMV3; Q8R0L0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 4A;
DE   AltName: Full=Calcium release-activated channel regulator 2B;
GN   Name=Cracr2b; Synonyms=Efcab4a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II, and FVB/N; TISSUE=Colon, Lung, and Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in store-operated Ca(2+) entry (SOCE).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EFCAB4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH48916.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC026645; AAH26645.1; -; mRNA.
DR   EMBL; BC048916; AAH48916.1; ALT_INIT; mRNA.
DR   EMBL; BC098333; AAH98333.1; -; mRNA.
DR   CCDS; CCDS22016.1; -.
DR   RefSeq; NP_001020274.2; NM_001025103.2.
DR   RefSeq; XP_006536237.1; XM_006536174.2.
DR   AlphaFoldDB; Q80ZJ8; -.
DR   SMR; Q80ZJ8; -.
DR   STRING; 10090.ENSMUSP00000055899; -.
DR   iPTMnet; Q80ZJ8; -.
DR   PhosphoSitePlus; Q80ZJ8; -.
DR   MaxQB; Q80ZJ8; -.
DR   PaxDb; Q80ZJ8; -.
DR   PRIDE; Q80ZJ8; -.
DR   ProteomicsDB; 277722; -.
DR   Antibodypedia; 42026; 55 antibodies from 21 providers.
DR   DNASU; 213573; -.
DR   Ensembl; ENSMUST00000053670; ENSMUSP00000055899; ENSMUSG00000048200.
DR   GeneID; 213573; -.
DR   KEGG; mmu:213573; -.
DR   UCSC; uc009klj.2; mouse.
DR   CTD; 283229; -.
DR   MGI; MGI:2446129; Cracr2b.
DR   VEuPathDB; HostDB:ENSMUSG00000048200; -.
DR   eggNOG; ENOG502QRXK; Eukaryota.
DR   GeneTree; ENSGT00440000033504; -.
DR   HOGENOM; CLU_047014_1_0_1; -.
DR   InParanoid; Q80ZJ8; -.
DR   OMA; GRREQTQ; -.
DR   OrthoDB; 1113066at2759; -.
DR   PhylomeDB; Q80ZJ8; -.
DR   TreeFam; TF329556; -.
DR   BioGRID-ORCS; 213573; 1 hit in 74 CRISPR screens.
DR   ChiTaRS; Cracr2b; mouse.
DR   PRO; PR:Q80ZJ8; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q80ZJ8; protein.
DR   Bgee; ENSMUSG00000048200; Expressed in parotid gland and 129 other tissues.
DR   ExpressionAtlas; Q80ZJ8; baseline and differential.
DR   Genevisible; Q80ZJ8; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008104; P:protein localization; ISO:MGI.
DR   GO; GO:2001256; P:regulation of store-operated calcium entry; IGI:MGI.
DR   GO; GO:0002115; P:store-operated calcium entry; ISS:UniProtKB.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..394
FT                   /note="EF-hand calcium-binding domain-containing protein
FT                   4A"
FT                   /id="PRO_0000283045"
FT   DOMAIN          28..63
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          65..97
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          174..353
FT                   /evidence="ECO:0000255"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N4Y2"
FT   CONFLICT        300
FT                   /note="E -> G (in Ref. 1; AAH98333)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   394 AA;  44438 MW;  8244A051A8C28EAE CRC64;
     MASPGLPGSG EGQEGEETTG VSARHGVEVL QQAQELFLLC DKDAKGFITR QDLQGLQSDL
     PLTPEQLEAV FESLDQAHTG FLTAREFCLG LGKFVGVESA PGGSPLRTSE ETFESGTGGS
     LEEEEEDVET FYTSLEKLGV ARVLGEQWAV RTLWVGLQRE RPELLGSLEE VLMRASACLE
     AAAREREGLE QALRRRESEH EREVRGLYEE LEQQLGEQRH RRQSQNLPRE EQRGHLELEL
     QTREQELERA GLRQRELEQQ LQARAAEQLE AQAQHIQLQR AYEAIRAQLD QAQEQLSRLE
     GEAQGRQEQT QRDVVAVSRN MQKEKLSLLR QLELLRELNL RLRDERDACE TKLLGSSHRK
     ALAIAHKPGP IYCCCCCGWA RPPRRGSGHL PSAR