ID   EFC4A_XENTR             Reviewed;         256 AA.
AC   A0JP75;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 4A;
DE   AltName: Full=Calcium release-activated channel regulator 2B;
GN   Name=cracr2b; Synonyms=efcab4a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the EFCAB4 family. {ECO:0000305}.
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DR   EMBL; BC127278; AAI27279.1; -; mRNA.
DR   RefSeq; NP_001090650.1; NM_001097181.1.
DR   AlphaFoldDB; A0JP75; -.
DR   SMR; A0JP75; -.
DR   STRING; 8364.ENSXETP00000041262; -.
DR   PaxDb; A0JP75; -.
DR   DNASU; 100036622; -.
DR   GeneID; 100036622; -.
DR   KEGG; xtr:100036622; -.
DR   CTD; 283229; -.
DR   Xenbase; XB-GENE-5729710; cracr2b.
DR   eggNOG; ENOG502QRXK; Eukaryota.
DR   InParanoid; A0JP75; -.
DR   OrthoDB; 1184845at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0002115; P:store-operated calcium entry; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Coiled coil; Metal-binding; Reference proteome; Repeat.
FT   CHAIN           1..256
FT                   /note="EF-hand calcium-binding domain-containing protein
FT                   4A"
FT                   /id="PRO_0000395808"
FT   DOMAIN          41..69
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          71..106
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          190..235
FT                   /evidence="ECO:0000255"
FT   BINDING         84
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         86
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         88
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         90
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         95
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   256 AA;  29990 MW;  236B66A51CF9AD7D CRC64;
     MAHLGSRRRM SPGLRTRIAH RKAHRTPPSP LIAEPDEMMG KAHELFQLCD KEDKGLITKR
     DLQRLQNELP LTPEQLEAVF DSLDQSNNGY LTPVEFSMGL GKLLGVNLSH EEEKENSMME
     ETFESGWSDG PDEEDDAEEM LFSATMEHLG ASRIFQEHKE IRDLWSRLRK ERPELLSHFE
     EFLYRVSSYI RDVHHEKDTL EQALKRKETD HGREVRCLYE EMEQQIKIER ERLLKKVLIK
     GDHGLKNYSH LIMSKV