ID   EFCB3_BOVIN             Reviewed;         438 AA.
AC   Q2T9P0;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 3;
GN   Name=EFCAB3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC111336; AAI11337.1; -; mRNA.
DR   RefSeq; NP_001033230.1; NM_001038141.2.
DR   AlphaFoldDB; Q2T9P0; -.
DR   SMR; Q2T9P0; -.
DR   STRING; 9913.ENSBTAP00000009115; -.
DR   PaxDb; Q2T9P0; -.
DR   PRIDE; Q2T9P0; -.
DR   GeneID; 524320; -.
DR   KEGG; bta:524320; -.
DR   CTD; 146779; -.
DR   eggNOG; KOG0027; Eukaryota.
DR   InParanoid; Q2T9P0; -.
DR   OrthoDB; 377537at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR043520; SPT21/EFCAB3.
DR   PANTHER; PTHR47500; PTHR47500; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Metal-binding; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..438
FT                   /note="EF-hand calcium-binding domain-containing protein 3"
FT                   /id="PRO_0000253546"
FT   DOMAIN          47..82
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          83..118
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          413..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         96
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         98
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         100
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         102
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         107
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         279
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q66HC0"
SQ   SEQUENCE   438 AA;  50198 MW;  CA25826DC9B489EB CRC64;
     MAVSEIKAKF KLNPLTKVPN FHSRRDKDLP GLLPCQLQHK ERKLSPSQMR AFQDAYNFFN
     KDKTGCIDLH GMMCTLAKLG MNLTKHDVHN ELRCADIDQD GKVNFSDFLK VLTDKNRFLK
     AVVPEKGTCL DLAGNPGILL FEILSKLIET SALPKKAISE IVSYFRRKFQ ETTSGMVWSP
     DTTGYGKRRF KPDICTPPSS STAAFANAAR IAIMKEKDLF KFLDELKKCN PPSDSPYSKI
     PIFPLFPNVD GVVMGKPFKD IQKLEMLKRK EPLNFFENYF FHKKDWKTQE ANIKPVDPTS
     GYTTDILTID QMLKRKQNWT VADAAAIKPH VKRATETYNL GIALEHRKQM LNLWRKIRGD
     LIGIESKNES FYDTFSTYTW SWNVCQELLS PKDLKLYDAH VNRNALHNSV FSSSSDISEC
     DTDTGRKRKR KGFKGFRQ