ID   EFCB3_MOUSE             Reviewed;         432 AA.
AC   Q80X60;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 3;
GN   Name=Efcab3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC050801; AAH50801.1; -; mRNA.
DR   CCDS; CCDS36355.1; -.
DR   RefSeq; NP_001074515.1; NM_001081046.1.
DR   RefSeq; XP_006534289.1; XM_006534226.3.
DR   AlphaFoldDB; Q80X60; -.
DR   SMR; Q80X60; -.
DR   STRING; 10090.ENSMUSP00000021029; -.
DR   iPTMnet; Q80X60; -.
DR   PhosphoSitePlus; Q80X60; -.
DR   PaxDb; Q80X60; -.
DR   PRIDE; Q80X60; -.
DR   Antibodypedia; 18612; 38 antibodies from 18 providers.
DR   DNASU; 70894; -.
DR   Ensembl; ENSMUST00000021029; ENSMUSP00000021029; ENSMUSG00000020690.
DR   GeneID; 70894; -.
DR   KEGG; mmu:70894; -.
DR   UCSC; uc007lwz.1; mouse.
DR   CTD; 146779; -.
DR   MGI; MGI:1918144; Efcab3.
DR   VEuPathDB; HostDB:ENSMUSG00000020690; -.
DR   eggNOG; KOG0027; Eukaryota.
DR   GeneTree; ENSGT00940000161358; -.
DR   HOGENOM; CLU_055753_0_0_1; -.
DR   InParanoid; Q80X60; -.
DR   OMA; IMNAMQN; -.
DR   OrthoDB; 47376at2759; -.
DR   PhylomeDB; Q80X60; -.
DR   TreeFam; TF328393; -.
DR   BioGRID-ORCS; 70894; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Efcab3; mouse.
DR   PRO; PR:Q80X60; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q80X60; protein.
DR   Bgee; ENSMUSG00000020690; Expressed in spermatid and 29 other tissues.
DR   ExpressionAtlas; Q80X60; baseline.
DR   Genevisible; Q80X60; MM.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR043520; SPT21/EFCAB3.
DR   PANTHER; PTHR47500; PTHR47500; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Metal-binding; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..432
FT                   /note="EF-hand calcium-binding domain-containing protein 3"
FT                   /id="PRO_0000253548"
FT   DOMAIN          45..80
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          81..116
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          394..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         94
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         96
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         98
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         100
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         105
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         273
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q66HC0"
SQ   SEQUENCE   432 AA;  49710 MW;  DF2BE5F356A1F0B5 CRC64;
     MAVSEIKATM KLKPLKAPVF HKRDKDLRGS FSDHLKHKES KLSPAQLEAF RNAYNFFTKD
     RTGCIDSHGL ISTIAKLGMN LNTYDIYNEL KCADLDRDGK INFSDFINVL TDKKLFLKAV
     VPEKKICLDL ANNPGILLFE ILSKFVETSS LHRKDIIELV SYFRKRFQES HSEIMWSSYG
     RRGLKSEICS PPRSSTAAFA NSARISIMKE RDLYKFLEAL KRCNLRTDSP YSKIPVFPLF
     PDVDGTVMGK PFKDTQKIEM LRRKEPLTFF EDYFFNKRDW KTQAMNVKPL KSASGYSDDI
     LAIDHLFKKK QHWTVTDAAA IKQHVKKATE SYNLGIALDH RKEMLNLWKK IRGDLVGIES
     NNESFYNTFS TYTWSWNVCQ ELLSAKDLRL HDASMNKSSP SNSGLSSPSD FSESDPETGR
     KRKRKSSRGF RQ