ID   EFCB3_RAT               Reviewed;         432 AA.
AC   Q66HC0; A0JPN9;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 3;
GN   Name=Efcab3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-273, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; BC081930; AAH81930.1; -; mRNA.
DR   EMBL; BC127522; AAI27523.1; -; mRNA.
DR   RefSeq; NP_001013994.1; NM_001013972.2.
DR   AlphaFoldDB; Q66HC0; -.
DR   STRING; 10116.ENSRNOP00000008019; -.
DR   CarbonylDB; Q66HC0; -.
DR   iPTMnet; Q66HC0; -.
DR   PhosphoSitePlus; Q66HC0; -.
DR   PaxDb; Q66HC0; -.
DR   GeneID; 303589; -.
DR   KEGG; rno:303589; -.
DR   UCSC; RGD:1305423; rat.
DR   CTD; 146779; -.
DR   RGD; 1305423; Efcab3.
DR   eggNOG; KOG0027; Eukaryota.
DR   InParanoid; Q66HC0; -.
DR   OrthoDB; 377537at2759; -.
DR   PhylomeDB; Q66HC0; -.
DR   PRO; PR:Q66HC0; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR043520; SPT21/EFCAB3.
DR   PANTHER; PTHR47500; PTHR47500; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   Calcium; Metal-binding; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..432
FT                   /note="EF-hand calcium-binding domain-containing protein 3"
FT                   /id="PRO_0000253549"
FT   DOMAIN          45..80
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          81..116
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          394..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         94
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         96
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         98
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         100
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         105
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         273
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   432 AA;  49804 MW;  3EC02849957526AA CRC64;
     MAISGFKGTL KLKPLKTPVF YKRDKDFRGY FSGHLQHKET KLSPAQLEAF RNAYNFFTKD
     RTGCIDSHGL MSTVAKLGMN LNAYDIYNEL KCADRDRDGK INFSDFIDVL TDKKLFLKAV
     VPEKRICLDL ANNPGILLFE ILSKFVEISA LHRKDIIELV SYFRKKFQES NSEILWSPYG
     RRAFKTDICS PPRSSTAAFA NSARISIMKE RDLYKFLEAL KRCNLRTDSP YSKIPVFPLF
     PDVDGVVLGK PFKDTQKLEM LRKREPLSFF EDYFFNKRDW KTQAMNVKPL KSASGYSDDI
     LAIDQLFKKK QHWTVSDAVA LKQHVKRATD TYHLGIALDH RKEMLNLWKK IRGDLVGLES
     NNESFYNTFS TYTWSWNVCQ ELLSAKDLRL HDANVNKTSP SNSGLSSPSD LSESDPETGR
     KRKRKSSRGF RQ