EFCB6_MACFA
ID EFCB6_MACFA Reviewed; 646 AA.
AC Q4R8T1;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=EF-hand calcium-binding domain-containing protein 6;
DE AltName: Full=DJ-1-binding protein;
DE Short=DJBP;
DE Flags: Fragment;
GN Name=EFCAB6; Synonyms=DJBP; ORFNames=QtsA-11542;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates the androgen receptor by recruiting
CC histone deacetylase complex, and protein DJ-1 antagonizes this
CC inhibition by abrogation of this complex. Microtubule inner protein
CC (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia
CC axoneme, which is required for motile cilia beating.
CC {ECO:0000250|UniProtKB:Q5THR3}.
CC -!- SUBUNIT: Binds PARK7. Part of a ternary complex containing PARK7,
CC EFCAB6/DJBP and AR (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5THR3}.
CC Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q5THR3}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE00490.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB168367; BAE00490.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q4R8T1; -.
DR SMR; Q4R8T1; -.
DR STRING; 9541.XP_005567114.1; -.
DR PRIDE; Q4R8T1; -.
DR eggNOG; KOG0027; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015070; EF_hand_DJBP.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF08976; EF-hand_11; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 6.
DR SUPFAM; SSF47473; SSF47473; 4.
DR PROSITE; PS50222; EF_HAND_2; 10.
PE 2: Evidence at transcript level;
KW Calcium; Cell projection; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN <1..646
FT /note="EF-hand calcium-binding domain-containing protein 6"
FT /id="PRO_0000246025"
FT DOMAIN <1..27
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 28..63
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 109..144
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 214..249
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 321..356
FT /note="EF-hand 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 357..392
FT /note="EF-hand 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 468..503
FT /note="EF-hand 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 504..539
FT /note="EF-hand 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 579..614
FT /note="EF-hand 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 615..646
FT /note="EF-hand 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 390..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..646
FT /note="Interaction with PARK7"
FT /evidence="ECO:0000250"
FT REGION 552..646
FT /note="Interaction with AR"
FT /evidence="ECO:0000250"
FT COMPBIAS 390..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 29
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1E8"
FT MOD_RES 435
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1E8"
FT MOD_RES 439
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1E8"
FT MOD_RES 449
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1E8"
FT NON_TER 1
SQ SEQUENCE 646 AA; 74091 MW; BACAD0B0B8AFE4AD CRC64;
FLETDNEGNG ILRRRDIKNA LYGFDIPLTP REFEKLWASY DTEGKGHITY QEFLQKLGVN
YSPAVHRPCA EDYFNFMGHF TKPQQLQEEM KELQQSTEKA VAARDKLVDC YQDISKAFTK
IDKSKTNYIS ICKMQKVLEE CGCSLTEGEL TNLLNSWGVS RHDNSINYLD FLRAVENSKS
TGAQPKEKEE SMPINFATLN PQEVVRKIQE VVESSQLALS TAFSALDKED TGFVKSTEFG
QVLKDFCHKL TDNQYHYFLR KLRIHLTPYI NWKYFLQNFS CFLEETAEEW AEKMPKGPPP
TSPKAMASRD ILARLHKAVT SHYHAITQEF ENFDTMKTNT ISREEFRAVC NRNVQILTDE
QFDRLWNEMP VNAKGRLKYP DFLSRFSSER AATPTATGDS AAAQRGSSVP DVSEGIRSAL
SLPNQELRPG SKPQSHPCTA ASTTAIPGTP PLQNCDPIES RLRKRIQGCW RQLLKECKEK
DVARQGDISA SEFLALVEKF NLDISKEECQ QLIIKYDLKN NGKFAYCDFI QSCVLLLKAK
ESSLMQRMKI QNAHKMKDSG AETSSFYSAL LRIQPKIVHC WRPMRRTFKS YDEAGTGLLS
VADFRTVLRQ YSINLSEEEF FHILEYYDKT LSSNISYNDF LRAFLQ
