ID   EFCB7_XENLA             Reviewed;         620 AA.
AC   Q6DCF6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 7;
GN   Name=efcab7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the ciliary Hedgehog (Hh) signaling.
CC       {ECO:0000250|UniProtKB:Q8VDY4}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000250|UniProtKB:Q8VDY4}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q8VDY4}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q8VDY4}.
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DR   EMBL; BC078089; AAH78089.1; -; mRNA.
DR   RefSeq; NP_001087154.1; NM_001093685.1.
DR   AlphaFoldDB; Q6DCF6; -.
DR   SMR; Q6DCF6; -.
DR   IntAct; Q6DCF6; 1.
DR   MaxQB; Q6DCF6; -.
DR   PRIDE; Q6DCF6; -.
DR   DNASU; 447043; -.
DR   GeneID; 447043; -.
DR   KEGG; xla:447043; -.
DR   CTD; 447043; -.
DR   Xenbase; XB-GENE-5749177; efcab7.L.
DR   OrthoDB; 1059411at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 447043; Expressed in testis and 19 other tissues.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Cell membrane; Cell projection; Membrane; Metal-binding;
KW   Reference proteome; Repeat.
FT   CHAIN           1..620
FT                   /note="EF-hand calcium-binding domain-containing protein 7"
FT                   /id="PRO_0000317268"
FT   DOMAIN          98..133
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          134..169
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          394..429
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         407
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         409
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         411
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         418
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   620 AA;  70810 MW;  2246EC0C359FA0FC CRC64;
     MANHSSLPSQ KYAASERQEY QKPQQNEEEI FYSVSRAAYL TVFKSSLDNI TTKDQLQLVL
     QQTGRNPSNR VLNKYWTPRT KELNFDDFCA ILKKEKPATK NELLKAFRKI DTNNKGYILH
     NDLYEILTTK GEKMSQEEVN SVFRLAEVNS NGKLDYNKFC STFFKTCEQC AKVASERMDS
     NSKAKRQQFG SYIEKSPERS SSPKSSHGNL KLFDSETSTR KENKSSRPSS ARSYKATMST
     VINMGIPGTR TAKLIEPNNL KDWHTTSTKG CFFLEDNGDI ISHHYKLQVS EKSTVYLTIK
     PLNLSKVEGK PSPWMSVDTS LFILKENNGR ADLVSFTELR NQETSGWKGE LGVGVYWLIP
     FTTGCRLRKK KKQTIKEARL VYRDGNEDLV LTPEFKSALS DMFDIIDLDG NGLLSLAEYN
     FFEMRTSGEK CDLDAWEVCK ENFETKKNEL TRQGFMELNL MEANDREGDP SDLWVTLQTM
     GYNKALEMTE ACPFVIEVHA EKCSPRLKAV SLESSNKQLQ GAVCKSVKLK GDAKPMDRYE
     DVIVYTYKND THVTSVMENK SDEKLILQVN NEQCKNCISS RGLQVFAVEL LPKSVMVCQH
     VMPLNEKQEW MYNCVQNILS