ID   EFCC1_MOUSE             Reviewed;         558 AA.
AC   Q9JJF6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=EF-hand and coiled-coil domain-containing protein 1;
DE   AltName: Full=Coiled-coil domain-containing protein 48;
GN   Name=Efcc1; Synonyms=Ccdc48; ORFNames=MNCb-4779;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RA   Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT   oligo-capping method.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9JJF6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9JJF6-2; Sequence=VSP_039450;
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DR   EMBL; AB041550; BAA95035.1; -; mRNA.
DR   EMBL; AC158626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS51840.1; -. [Q9JJF6-1]
DR   RefSeq; NP_001153169.1; NM_001159697.1. [Q9JJF6-1]
DR   RefSeq; XP_017177180.1; XM_017321691.1. [Q9JJF6-1]
DR   AlphaFoldDB; Q9JJF6; -.
DR   SMR; Q9JJF6; -.
DR   STRING; 10090.ENSMUSP00000138649; -.
DR   iPTMnet; Q9JJF6; -.
DR   PhosphoSitePlus; Q9JJF6; -.
DR   jPOST; Q9JJF6; -.
DR   MaxQB; Q9JJF6; -.
DR   PaxDb; Q9JJF6; -.
DR   PRIDE; Q9JJF6; -.
DR   ProteomicsDB; 277762; -. [Q9JJF6-1]
DR   ProteomicsDB; 277763; -. [Q9JJF6-2]
DR   Antibodypedia; 55576; 23 antibodies from 9 providers.
DR   Ensembl; ENSMUST00000159570; ENSMUSP00000138649; ENSMUSG00000068263. [Q9JJF6-1]
DR   GeneID; 58229; -.
DR   KEGG; mmu:58229; -.
DR   UCSC; uc009ctu.1; mouse. [Q9JJF6-1]
DR   CTD; 79825; -.
DR   MGI; MGI:3611451; Efcc1.
DR   VEuPathDB; HostDB:ENSMUSG00000068263; -.
DR   eggNOG; ENOG502QUT5; Eukaryota.
DR   GeneTree; ENSGT00950000183014; -.
DR   HOGENOM; CLU_456299_0_0_1; -.
DR   InParanoid; Q9JJF6; -.
DR   OMA; PTHEGRP; -.
DR   PhylomeDB; Q9JJF6; -.
DR   TreeFam; TF330736; -.
DR   BioGRID-ORCS; 58229; 2 hits in 69 CRISPR screens.
DR   ChiTaRS; Efcc1; mouse.
DR   PRO; PR:Q9JJF6; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q9JJF6; protein.
DR   Bgee; ENSMUSG00000068263; Expressed in superior frontal gyrus and 48 other tissues.
DR   ExpressionAtlas; Q9JJF6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR031601; CCD48.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF15799; CCD48; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..558
FT                   /note="EF-hand and coiled-coil domain-containing protein 1"
FT                   /id="PRO_0000342342"
FT   DOMAIN          43..78
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          161..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          179..304
FT                   /evidence="ECO:0000255"
FT   COILED          453..495
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        308..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..359
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         305..558
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_039450"
SQ   SEQUENCE   558 AA;  61881 MW;  C83E160F53B86FE3 CRC64;
     MESSAGDPYR RPARRTQWLL SALAHHYGLD RGVENEIVVL ATGLDQYLQE VFHHLDCRGA
     GRLPRADFRA LCAVLGLNAD GETATEDANS AEAASTNPAA GMIAGGDADV REEARLALRA
     DPPELTFRQF HARLCGYFSS RAGPRLPRGA LSEHIETQIR LRRPRRRRRP GSPSLHGGAY
     GERVAHLEEE NSSLRELVED LRAALQSSDA RCLALQVGLW KSQSDIPEAA AHELQRAQGA
     LAEAEARARR LQRGQVEVRL RTEEARQAVR RSLHRVRELE ALARRVPCLQ RQVQRLEAEL
     RGYRSEGPQL LTPQQASPRP GNRNGEPTAG GTRDSDTTPE GVQRSDSRDT DEEDEQLFRS
     VEGQAASEEE EEERWQEKPG RPQAHGEVPL VQPSGCVSRC DDQTAETLKA SFGHCDGAEH
     ICTLELETHV TRLGEQLQTL GTPEEEAELQ QMVEAEHLRL ELQMVETERV RLSLLEEKLV
     DVLQLLQRLR DLNISKRALG KMLLNALDRN PSQEGTCGTL AILDTLHQAL VGCELLQRNP
     SAPASTAPAH TNPFLISC