ID   EFEMO_STAA3             Reviewed;         284 AA.
AC   Q2FJS0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Efem/EfeO family lipoprotein;
DE   Flags: Precursor;
GN   OrderedLocusNames=SAUSA300_0344;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD22873.1; -; Genomic_DNA.
DR   RefSeq; WP_000737193.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FJS0; -.
DR   SMR; Q2FJS0; -.
DR   PRIDE; Q2FJS0; -.
DR   EnsemblBacteria; ABD22873; ABD22873; SAUSA300_0344.
DR   KEGG; saa:SAUSA300_0344; -.
DR   HOGENOM; CLU_050342_0_1_9; -.
DR   OMA; WTGWHRL; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14656; Imelysin-like_EfeO; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF09375; Peptidase_M75; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           18..284
FT                   /note="Efem/EfeO family lipoprotein"
FT                   /id="PRO_0000278317"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   284 AA;  32259 MW;  C54CD98EAF34FA00 CRC64;
     MKKLTTLLLA STLLIAACGN DDSKKDDSKT SKKDDGVKAE LKQATKAYDK YTDEQLNEFL
     KGTEKFVKAI ENNDMAQAKA LYPKVRMYYE RSEPVAEAFG DLDPKIDARL ADMKEEKKEK
     EWSGYHKIEK ALYEDKKIDD VTKKDAQQLL KDAKELHAKA DTLDIIPKLM LQGSVDLLNE
     VATSKITGEE EIYSHTDLYD FKANVEGAQK IYDLFKPILE KKDKKLSDDI QMNFDKVNQL
     LDKYKDNNGG YESFEKVSKK DRKAFADAVN ALGEPLSKMA VITE