ID   EFEMO_STAAC             Reviewed;         284 AA.
AC   Q5HIV1;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Efem/EfeO family lipoprotein;
DE   Flags: Precursor;
GN   OrderedLocusNames=SACOL0414;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW38883.1; -; Genomic_DNA.
DR   RefSeq; WP_000737196.1; NC_002951.2.
DR   AlphaFoldDB; Q5HIV1; -.
DR   SMR; Q5HIV1; -.
DR   EnsemblBacteria; AAW38883; AAW38883; SACOL0414.
DR   KEGG; sac:SACOL0414; -.
DR   HOGENOM; CLU_050342_0_1_9; -.
DR   OMA; WTGWHRL; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14656; Imelysin-like_EfeO; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF09375; Peptidase_M75; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           18..284
FT                   /note="Efem/EfeO family lipoprotein"
FT                   /id="PRO_0000278310"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   284 AA;  32247 MW;  B84CD98EB234F392 CRC64;
     MKKLTTLLLA STLLIAACGN DDSKKDDSKT SKKDDGVKAE LKQATKAYDK YTDEQLNEFL
     KGTEKFVKAI ENNDMAQAKA LYPKVRMYYE RSEPVAEAFG DLDPKIDARL ADMKEEKKEK
     EWSGYHKIEK ALYEDKKIDD VTKKDAQQLL KDAKELHAKA DTLDITPKLM LQGSVDLLNE
     VATSKITGEE EIYSHTDLYD FKANVEGAQK IYDLFKPILE KKDKKLSDDI QMNFDKVNQL
     LDKYKDNNGG YESFEKVSKK DRKAFADAVN ALGEPLSKMA VITE