ID   EFEMO_STAAR             Reviewed;         284 AA.
AC   Q6GJX5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Efem/EfeO family lipoprotein;
DE   Flags: Precursor;
GN   OrderedLocusNames=SAR0340;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG39363.1; -; Genomic_DNA.
DR   RefSeq; WP_000737200.1; NC_002952.2.
DR   AlphaFoldDB; Q6GJX5; -.
DR   SMR; Q6GJX5; -.
DR   KEGG; sar:SAR0340; -.
DR   HOGENOM; CLU_050342_0_1_9; -.
DR   OMA; WTGWHRL; -.
DR   OrthoDB; 1430947at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14656; Imelysin-like_EfeO; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF09375; Peptidase_M75; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           18..284
FT                   /note="Efem/EfeO family lipoprotein"
FT                   /id="PRO_0000278311"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   284 AA;  32246 MW;  142CD12CB46BC181 CRC64;
     MKKLTTLLLA STLLIAACGN DDSKKDDSKT SKKDDGVKAE LKQATKAYDK YTDEQLNEFL
     KGTEKFVKAI ENNDMAQAKA LYPKVRMYYE RSEPVAEAFG DLDPKIDARL ADMKEEKKEK
     EWSGYHKIEK ALYEDKKIDD VTKKDAQQLL KNAKELHAKA DTLDITPKLM LQGSVDLLNE
     VATSKITGEE EIYSHTDLYD FKANVEGAQK IYDLFKPILE KKDKKLSDDI QMNFDKVNKL
     LDKYKDNNGG YESFEKVSKK DRKAFADAVN ALGEPLSKMA VITE