ID   EFEO_ECO57              Reviewed;         375 AA.
AC   Q8XAS6; Q7AFM5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Iron uptake system component EfeO;
DE   Flags: Precursor;
GN   Name=efeO; OrderedLocusNames=Z1520, ECs1264;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=17627767; DOI=10.1111/j.1365-2958.2007.05802.x;
RA   Cao J., Woodhall M.R., Alvarez J., Cartron M.L., Andrews S.C.;
RT   "EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH
RT   Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in
RT   E. coli O157:H7.";
RL   Mol. Microbiol. 65:857-875(2007).
CC   -!- FUNCTION: Involved in Fe(2+) uptake. Could be an iron-binding and/or
CC       electron-transfer component (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Part of a ferrous iron transporter composed of EfeU,
CC       EfeO and EfeB. {ECO:0000269|PubMed:17627767}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG55636.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34687.1; -; Genomic_DNA.
DR   PIR; H85646; H85646.
DR   PIR; H90786; H90786.
DR   RefSeq; NP_309291.1; NC_002695.1.
DR   RefSeq; WP_000154396.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XAS6; -.
DR   SMR; Q8XAS6; -.
DR   STRING; 155864.EDL933_1444; -.
DR   PRIDE; Q8XAS6; -.
DR   EnsemblBacteria; AAG55636; AAG55636; Z1520.
DR   EnsemblBacteria; BAB34687; BAB34687; ECs_1264.
DR   GeneID; 60900698; -.
DR   GeneID; 913843; -.
DR   KEGG; ece:Z1520; -.
DR   KEGG; ecs:ECs_1264; -.
DR   PATRIC; fig|386585.9.peg.1371; -.
DR   eggNOG; COG2822; Bacteria.
DR   HOGENOM; CLU_050342_2_1_6; -.
DR   OMA; WTGWHRL; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd14656; Imelysin-like_EfeO; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR028096; EfeO_Cupredoxin.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF13473; Cupredoxin_1; 1.
DR   Pfam; PF09375; Peptidase_M75; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
PE   1: Evidence at protein level;
KW   Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..375
FT                   /note="Iron uptake system component EfeO"
FT                   /id="PRO_0000278555"
SQ   SEQUENCE   375 AA;  41124 MW;  A2115A8E1B1DF09F CRC64;
     MTINFRRNAL QLSVAALFSS AFMANAADVP QVKVTVTDKQ CEPMTITVNA GKTQFIIQNH
     SQKALEWEIL KGVMVVEERE NIAPGFSQKM TANLQPGEYD MTCGLLTNPK GKLIVKGEAT
     ADAAQSDALL SLGGAITAYK AYVMAETTQL VTDTKAFTDA IKAGDIEKAK ALYAPTRQHY
     ERIEPIAELF SDLDGSIDAR EDDYEQKAAD PKFTGFHRLE KALFGDNTTK GMDQYADQLY
     TDVVDLQKRI SELAFPPSKV VGGAAGLIEE VAASKISGEE DRYSHTDLWD FQANVEGSQK
     IVDLLRPQLQ KANPELLAKV DANFKKVDTI LAKYRTKDGF ETYDKLTDAD RNALKGPITA
     LAEDLAQLRG VLGLD