ID   EFEO_ECOL6              Reviewed;         375 AA.
AC   Q8FJ35;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Iron uptake system component EfeO;
DE   Flags: Precursor;
GN   Name=efeO; OrderedLocusNames=c1156;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
RN   [2]
RP   INDUCTION.
RC   STRAIN=O6:K5:H1 / Nissle 1917;
RX   PubMed=16987175; DOI=10.1111/j.1365-2958.2006.05326.x;
RA   Grosse C., Scherer J., Koch D., Otto M., Taudte N., Grass G.;
RT   "A new ferrous iron-uptake transporter, EfeU (YcdN), from Escherichia
RT   coli.";
RL   Mol. Microbiol. 62:120-131(2006).
CC   -!- FUNCTION: Involved in Fe(2+) uptake. Could be an iron-binding and/or
CC       electron-transfer component (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Part of a ferrous iron transporter composed of EfeU,
CC       EfeO and EfeB (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- INDUCTION: Expressed in response to iron deprivation at pH 7.
CC       {ECO:0000269|PubMed:16987175}.
CC   -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN79624.1; -; Genomic_DNA.
DR   RefSeq; WP_000154372.1; NC_004431.1.
DR   AlphaFoldDB; Q8FJ35; -.
DR   SMR; Q8FJ35; -.
DR   STRING; 199310.c1156; -.
DR   EnsemblBacteria; AAN79624; AAN79624; c1156.
DR   KEGG; ecc:c1156; -.
DR   eggNOG; COG2822; Bacteria.
DR   HOGENOM; CLU_050342_2_1_6; -.
DR   OMA; WTGWHRL; -.
DR   BioCyc; ECOL199310:C1156-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd14656; Imelysin-like_EfeO; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR028096; EfeO_Cupredoxin.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF13473; Cupredoxin_1; 1.
DR   Pfam; PF09375; Peptidase_M75; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
PE   2: Evidence at transcript level;
KW   Periplasm; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..375
FT                   /note="Iron uptake system component EfeO"
FT                   /id="PRO_0000278308"
SQ   SEQUENCE   375 AA;  41163 MW;  5E10AF0AE76069FA CRC64;
     MTINFRRNAL QLSVAALFSS AFMANAADIP QVKVTVTDKQ CEPMIITVNA GKTQFIIQNH
     SQKALEWEIL KGVMVVEERE NIAPGFSQKM TANLQPGEYD MTCGLLTNPK GKLIVKGEAT
     ADAAQSDALL SLGGAITAYK AYVMAETTQL VTDTKAFTDA IKAGDIEKAK ALYAPTRQHY
     ERIEPIAELF SDLDGSIDAR EDDYEQKAAD PKFTGFHRLE KALFGDNTTK GMDKYADQLY
     TDVVDLQKRI SELAFPPSKV VGGAAGLIEE VAASKISGEE DRYSHTDLWD FQANVEGSQK
     IVDLLRPQLQ KANPELLAKV DANFKKVDTI LAKYRTKDGF ENYDKLTDAD RNALKGPITA
     LAEDLAQLRG VLGLD