ID   EFEO_ECOUT              Reviewed;         375 AA.
AC   Q1RDJ9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Iron uptake system component EfeO;
DE   Flags: Precursor;
GN   Name=efeO; OrderedLocusNames=UTI89_C1081;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Involved in Fe(2+) uptake. Could be an iron-binding and/or
CC       electron-transfer component (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Part of a ferrous iron transporter composed of EfeU,
CC       EfeO and EfeB (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
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DR   EMBL; CP000243; ABE06565.1; -; Genomic_DNA.
DR   RefSeq; WP_000154379.1; NC_007946.1.
DR   AlphaFoldDB; Q1RDJ9; -.
DR   SMR; Q1RDJ9; -.
DR   PRIDE; Q1RDJ9; -.
DR   EnsemblBacteria; ABE06565; ABE06565; UTI89_C1081.
DR   KEGG; eci:UTI89_C1081; -.
DR   HOGENOM; CLU_050342_2_1_6; -.
DR   OMA; WTGWHRL; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd14656; Imelysin-like_EfeO; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR028096; EfeO_Cupredoxin.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF13473; Cupredoxin_1; 1.
DR   Pfam; PF09375; Peptidase_M75; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
PE   3: Inferred from homology;
KW   Periplasm; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..375
FT                   /note="Iron uptake system component EfeO"
FT                   /id="PRO_0000278554"
SQ   SEQUENCE   375 AA;  41151 MW;  5614AB022FAB9833 CRC64;
     MTINFRRNAL QLSVAALFSS AFMANAADIP QVKVTVTDKQ CEPMTITVNA GKTQFIIQNH
     SQKALEWEIL KGVMVVEERE NIAPGFSQKM TANLQPGEYD MTCGLLTNPK GKLIVKGEAT
     ADAAQSDALL SLGGAITAYK AYVMAETTQL VTDTKAFTDA IKAGDIEKAK ALYAPTRQHY
     ERIEPIAELF SDLDGSIDAR EDDYEQKAAD PKFTGFHRLE KALFGDNTTK GMDKYADQLY
     TDVVDLQKRI SELAFPPSKV VGGAAGLIEE VAASKISGEE DRYSHTDLWD FQANVEGSQK
     IVDLLRPQLQ KANPELLAKV DANFKKVDTI LAKYRTKDGF ENYDKLTDAD RNALKGPITA
     LAEDLAQLRG VLGLD