ID   EFEO_YERPE              Reviewed;         376 AA.
AC   Q0WFT9; Q74V01; Q8D0B8;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Iron uptake system component EfeO;
DE   Flags: Precursor;
GN   Name=efeO; OrderedLocusNames=YPO1855, y2451, YP_1538;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Involved in Fe(2+) uptake. Could be an iron-binding and/or
CC       electron-transfer component (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Part of a ferrous iron transporter composed of EfeU,
CC       EfeO and EfeB (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EfeM/EfeO family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM86008.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAS61773.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL20495.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM86008.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS61773.1; ALT_INIT; Genomic_DNA.
DR   PIR; AD0226; AD0226.
DR   RefSeq; WP_002211166.1; NZ_WUCM01000005.1.
DR   RefSeq; YP_002346849.1; NC_003143.1.
DR   PDB; 5TW9; X-ray; 1.50 A; A/B/C/D/E/F=314-376.
DR   PDBsum; 5TW9; -.
DR   AlphaFoldDB; Q0WFT9; -.
DR   SMR; Q0WFT9; -.
DR   STRING; 214092.YPO1855; -.
DR   PaxDb; Q0WFT9; -.
DR   DNASU; 1147398; -.
DR   EnsemblBacteria; AAM86008; AAM86008; y2451.
DR   EnsemblBacteria; AAS61773; AAS61773; YP_1538.
DR   GeneID; 57976726; -.
DR   KEGG; ype:YPO1855; -.
DR   KEGG; ypk:y2451; -.
DR   KEGG; ypm:YP_1538; -.
DR   PATRIC; fig|214092.21.peg.2220; -.
DR   eggNOG; COG2822; Bacteria.
DR   HOGENOM; CLU_050342_2_1_6; -.
DR   OMA; WTGWHRL; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd14656; Imelysin-like_EfeO; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR028096; EfeO_Cupredoxin.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034981; Imelysin-like_EfeO/Algp7.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF13473; Cupredoxin_1; 1.
DR   Pfam; PF09375; Peptidase_M75; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..376
FT                   /note="Iron uptake system component EfeO"
FT                   /id="PRO_0000278561"
FT   HELIX           317..333
FT                   /evidence="ECO:0007829|PDB:5TW9"
FT   HELIX           344..346
FT                   /evidence="ECO:0007829|PDB:5TW9"
FT   HELIX           349..372
FT                   /evidence="ECO:0007829|PDB:5TW9"
SQ   SEQUENCE   376 AA;  41353 MW;  19B8FA8B86165ACB CRC64;
     MSIWFFRRTA LHAALLSLPV FAISAQAADI QQVKITVNDK QCEPMALTVP AGKTQFIVHN
     VSQKGLEWEI LKGVMVVEER ENIAPGFTQK MTANLEPGEY DMTCGLLSNP KGKLTVTVAA
     GEQAPVKPDA MALVGPIAEY KVYVTQEVAQ LVSQTKAFTD AVKAGDLALA RKLYAPTRQH
     YERIEPIAEL FSDLDGSIDA REDDFEQKSA DPKFTGFHRL EKILFGDNTT KGADKFADLL
     YQDTLELQKR IAGLTFAPNK VVGGAAGLIE EVAASKISGE EDRYSRTDLW DFQANVDGAQ
     KIVNLLRPLL EKADKPLLQK IDANFNTVDS VLAKYRTKEG YESYEKLTDA DRNAMKGPIT
     ALAEDLAQLR GVLGLD