EFEU_BACSU
ID EFEU_BACSU Reviewed; 481 AA.
AC P39595;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Ferrous iron permease EfeU;
DE AltName: Full=Fe(2+) ion permease EfeU;
DE AltName: Full=Ferrous iron uptake protein;
DE Flags: Precursor;
GN Name=efeU; Synonyms=ywbL; OrderedLocusNames=BSU38280; ORFNames=ipa-27d;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7934828; DOI=10.1111/j.1365-2958.1993.tb01963.x;
RA Glaser P., Kunst F., Arnaud M., Coudart M.P., Gonzales W., Hullo M.-F.,
RA Ionescu M., Lubochinsky B., Marcelino L., Moszer I., Presecan E.,
RA Santana M., Schneider E., Schweizer J., Vertes A., Rapoport G., Danchin A.;
RT "Bacillus subtilis genome project: cloning and sequencing of the 97 kb
RT region from 325 degrees to 333 degrees.";
RL Mol. Microbiol. 10:371-384(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO 180-182.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP FUNCTION IN IRON UPTAKE.
RC STRAIN=168 / CU1065;
RX PubMed=16672620; DOI=10.1128/jb.188.10.3664-3673.2006;
RA Ollinger J., Song K.-B., Antelmann H., Hecker M., Helmann J.D.;
RT "Role of the Fur regulon in iron transport in Bacillus subtilis.";
RL J. Bacteriol. 188:3664-3673(2006).
CC -!- FUNCTION: Uptake of Fe(2+) ions across the membrane.
CC {ECO:0000305|PubMed:16672620}.
CC -!- SUBUNIT: Part of a ferrous iron transporter composed of EfeU, EfeM and
CC EfeN. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC 9.A.10.1) family. {ECO:0000305}.
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DR EMBL; X73124; CAA51583.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15854.2; -; Genomic_DNA.
DR PIR; S39682; S39682.
DR RefSeq; NP_391707.2; NC_000964.3.
DR RefSeq; WP_003243918.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P39595; -.
DR SMR; P39595; -.
DR STRING; 224308.BSU38280; -.
DR TCDB; 2.A.108.2.5; the iron/lead transporter (ilt) family.
DR PaxDb; P39595; -.
DR PRIDE; P39595; -.
DR EnsemblBacteria; CAB15854; CAB15854; BSU_38280.
DR GeneID; 938520; -.
DR KEGG; bsu:BSU38280; -.
DR PATRIC; fig|224308.179.peg.4144; -.
DR eggNOG; COG0672; Bacteria.
DR InParanoid; P39595; -.
DR OMA; PVIMVKG; -.
DR PhylomeDB; P39595; -.
DR BioCyc; BSUB:BSU38280-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0034755; P:iron ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004923; FTR1/Fip1/EfeU.
DR PANTHER; PTHR31632; PTHR31632; 1.
DR Pfam; PF03239; FTR1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Ion transport; Iron; Iron transport; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..481
FT /note="Ferrous iron permease EfeU"
FT /id="PRO_0000010305"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 180..182
FT /note="SEE -> CHQ (in Ref. 1; CAA51583)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 481 AA; 52388 MW; F3B7562A311B2F3E CRC64;
MARGLALILF SLLMVFGSAA HAEDDPIAAL IQLNKQMIKS VKDGDMDSAQ QTFDTFKAKW
KKEEPSIKKE NLSSHSEMDA NIAMISLSFI NQDARKLKTQ LEELASHLET YQQAVVLKKT
SSGQSRASLT AYIQSLKDTK QFIEKKQLDE ASSAIDNLVT SWLAVEGDVV SQSKEAYTTS
EENLALMKAE IGSHPEKVSK QIDEMIQLLE PIASSSYSWW DAALIPVREG MEALLVIGAL
LTMTKKARVT RSSTWIWGGA SAGMAVSLAA GIGVTVLFSS SVFGENNFLL GGVTGVLSAV
MLLYVGVWLH RNASMDKWRE KINIQKSQAL KKRSLLSFAL IAFLAVVREG LETVIFFIGL
VGKLPLTELI GGTAAGLIVL VIVGVLMIKL GMRIPLKPFF LLSMAVVLYM CVKFLGTGVH
SLQLAGILPS DAESWLPSVS VLGIYPSVYS TIPQMLILLF LLIALVSEAA KHFTNGKELT
K
