EFEU_ECO57
ID EFEU_ECO57 Reviewed; 276 AA.
AC Q8XAS8; Q7AFM6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Ferrous iron permease EfeU;
DE AltName: Full=Fe(2+) ion permease EfeU;
DE AltName: Full=Ferrous iron uptake protein;
GN Name=efeU; OrderedLocusNames=Z1519, ECs1263;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
RN [3]
RP FUNCTION, AND SUBUNIT.
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=17627767; DOI=10.1111/j.1365-2958.2007.05802.x;
RA Cao J., Woodhall M.R., Alvarez J., Cartron M.L., Andrews S.C.;
RT "EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH
RT Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in
RT E. coli O157:H7.";
RL Mol. Microbiol. 65:857-875(2007).
CC -!- FUNCTION: Uptake of Fe(2+) ions across the membrane.
CC {ECO:0000269|PubMed:17627767}.
CC -!- SUBUNIT: Part of a ferrous iron transporter composed of EfeU, EfeO and
CC EfeB. {ECO:0000269|PubMed:17627767}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC 9.A.10.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG55635.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE005174; AAG55635.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000007; BAB34686.1; -; Genomic_DNA.
DR PIR; G85646; G85646.
DR PIR; G90786; G90786.
DR RefSeq; NP_309290.1; NC_002695.1.
DR RefSeq; WP_000497942.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8XAS8; -.
DR STRING; 155864.EDL933_1443; -.
DR EnsemblBacteria; AAG55635; AAG55635; Z1519.
DR EnsemblBacteria; BAB34686; BAB34686; ECs_1263.
DR GeneID; 60900699; -.
DR GeneID; 912835; -.
DR KEGG; ece:Z1519; -.
DR KEGG; ecs:ECs_1263; -.
DR PATRIC; fig|386585.9.peg.1370; -.
DR eggNOG; COG0672; Bacteria.
DR HOGENOM; CLU_077905_0_0_6; -.
DR OMA; WYGTLLK; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR InterPro; IPR005217; FTR1-like.
DR InterPro; IPR004923; FTR1/Fip1/EfeU.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31632; PTHR31632; 1.
DR Pfam; PF03239; FTR1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00145; TIGR00145; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..276
FT /note="Ferrous iron permease EfeU"
FT /id="PRO_0000277544"
FT TOPO_DOM 1
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..34
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..69
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..147
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..244
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..276
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 276 AA; 30344 MW; D622043A62586F45 CRC64;
MFVPFLIMLR EGLEAALIVS LIASYLKRTQ RGRWIGVMWI GVLLAAALCL GLGIFINETT
GEFPQKEQEL FEGIVAVIAV VILTWMVFWM RKVSRNVKVQ LEQAVDSALQ RGNHHGWALV
MMVFFAVARE GLESVFFLLA AFQQDVGIWP PLGAMLGLAT AVVLGFLLYW GGIRLNLGAF
FKWTSLFILF VAAGLAAGAI RAFHEAGLWN HFQEIAFDMS AVLSTHSLFG TLMEGIFGYQ
EAPSVSEVAV WFIYLIPALV AFALPPRAGA TASRSA
