ID   EFEU_SHIFL              Reviewed;         235 AA.
AC   Q83LK5; Q7UCZ5;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Ferrous iron permease EfeU;
DE   AltName: Full=Fe(2+) ion permease EfeU;
DE   AltName: Full=Ferrous iron uptake protein;
GN   Name=efeU; OrderedLocusNames=SF1019, S1089;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Uptake of Fe(2+) ions across the membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a ferrous iron transporter composed of EfeU, EfeO and
CC       EfeB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC       9.A.10.1) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN42645.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN42645.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP16530.1; -; Genomic_DNA.
DR   RefSeq; NP_706938.1; NC_004337.2.
DR   AlphaFoldDB; Q83LK5; -.
DR   STRING; 198214.SF1019; -.
DR   EnsemblBacteria; AAN42645; AAN42645; SF1019.
DR   EnsemblBacteria; AAP16530; AAP16530; S1089.
DR   GeneID; 1023989; -.
DR   KEGG; sfl:SF1019; -.
DR   KEGG; sfx:S1089; -.
DR   PATRIC; fig|198214.7.peg.1183; -.
DR   HOGENOM; CLU_077905_0_0_6; -.
DR   OMA; WYGTLLK; -.
DR   OrthoDB; 2018349at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   InterPro; IPR004923; FTR1/Fip1/EfeU.
DR   PANTHER; PTHR31632; PTHR31632; 1.
DR   Pfam; PF03239; FTR1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..235
FT                   /note="Ferrous iron permease EfeU"
FT                   /id="PRO_0000277546"
FT   TOPO_DOM        1..28
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..106
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..177
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..203
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..235
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   235 AA;  25826 MW;  7E5E07228EEB9F56 CRC64;
     MTSRSRQAAY SGIFINETTG EFPQKEQELF EGIVAVIAVV ILTWMVFWMR KVSRNVKVQL
     EQAVDSALQR GNHHGWALVM MVFFAVAREG LESVFFLLAA FQQDVGIWPP LGAMLGLATA
     VVLGFLLYWG GIRLNLGAFF KWTSLFILFV AAGLAAGAIR AFHEAGLWNH FQEIAFDMSA
     VLSTHSLFGT LMEGIFGYQE APSVSEVAVW FIYLIPALVA FALPPRAGAT ASRSA