EFEU_YERPE
ID EFEU_YERPE Reviewed; 282 AA.
AC Q0WFU0; Q74V00; Q8D0B7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Ferrous iron permease EfeU;
DE AltName: Full=Fe(2+) ion permease EfeU;
DE AltName: Full=Ferrous iron uptake protein;
GN Name=efeU; Synonyms=fTR11; OrderedLocusNames=YPO1854, y2452, YP_1539;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Uptake of Fe(2+) ions across the membrane. {ECO:0000250}.
CC -!- SUBUNIT: Part of a ferrous iron transporter composed of EfeU, EfeO and
CC EfeB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC 9.A.10.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM86009.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAS61774.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL20494.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM86009.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS61774.1; ALT_INIT; Genomic_DNA.
DR PIR; AC0226; AC0226.
DR RefSeq; WP_002211165.1; NZ_WUCM01000005.1.
DR RefSeq; YP_002346848.1; NC_003143.1.
DR AlphaFoldDB; Q0WFU0; -.
DR STRING; 214092.YPO1854; -.
DR PaxDb; Q0WFU0; -.
DR DNASU; 1147399; -.
DR EnsemblBacteria; AAM86009; AAM86009; y2452.
DR EnsemblBacteria; AAS61774; AAS61774; YP_1539.
DR GeneID; 57976727; -.
DR KEGG; ype:YPO1854; -.
DR KEGG; ypk:y2452; -.
DR KEGG; ypm:YP_1539; -.
DR PATRIC; fig|214092.21.peg.2219; -.
DR eggNOG; COG0672; Bacteria.
DR HOGENOM; CLU_077905_0_0_6; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0034755; P:iron ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004923; FTR1/Fip1/EfeU.
DR PANTHER; PTHR31632; PTHR31632; 1.
DR Pfam; PF03239; FTR1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..282
FT /note="Ferrous iron permease EfeU"
FT /id="PRO_0000277549"
FT TOPO_DOM 1
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..69
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..147
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..244
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 282 AA; 30688 MW; C6D394DB1BD68055 CRC64;
MFVPFLIMFR EGLEAALIVS LIASYLKRTQ RGQWMGAVWV GVVVAAVLCL AIGIFINETT
GEFPQKQQEL FEGIIAVVAV CILTYMVFWM RKVSKSVKVH LEGAIDNALN SGRGQGWALV
AMVFFAVARE GLESVFFLLA AFQQDVGIGA PIGAILGLVC AILVGMAIYW GGVKLHLAKF
FKWTSLFILF VAAGLAAGAI RAFHEAGLWN HFQDIAFDLT DVLSTHSLLG TFLEGMFGYQ
EAPTVSEVSV YFIYLIPALI LFFLPPRSTA GSAIAAARKI NP
