ID   EFEU_YERPN              Reviewed;         282 AA.
AC   Q1CHD3; C4GUG1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Ferrous iron permease EfeU;
DE   AltName: Full=Fe(2+) ion permease EfeU;
DE   AltName: Full=Ferrous iron uptake protein;
GN   Name=efeU; OrderedLocusNames=YPN_2269; ORFNames=YP516_2550;
OS   Yersinia pestis bv. Antiqua (strain Nepal516).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=377628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RA   Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA   Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R.,
RA   Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.;
RT   "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of Fe(2+) ions across the membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a ferrous iron transporter composed of EfeU, EfeO and
CC       EfeB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC       9.A.10.1) family. {ECO:0000305}.
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DR   EMBL; CP000305; ABG18597.1; -; Genomic_DNA.
DR   EMBL; ACNQ01000013; EEO76348.1; -; Genomic_DNA.
DR   RefSeq; WP_002211165.1; NZ_ACNQ01000013.1.
DR   AlphaFoldDB; Q1CHD3; -.
DR   EnsemblBacteria; ABG18597; ABG18597; YPN_2269.
DR   GeneID; 57976727; -.
DR   KEGG; ypn:YPN_2269; -.
DR   HOGENOM; CLU_077905_0_0_6; -.
DR   OMA; WYGTLLK; -.
DR   Proteomes; UP000008936; Chromosome.
DR   GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   InterPro; IPR004923; FTR1/Fip1/EfeU.
DR   PANTHER; PTHR31632; PTHR31632; 1.
DR   Pfam; PF03239; FTR1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..282
FT                   /note="Ferrous iron permease EfeU"
FT                   /id="PRO_0000277551"
FT   TOPO_DOM        1
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..69
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..118
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..147
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..244
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..282
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   282 AA;  30688 MW;  C6D394DB1BD68055 CRC64;
     MFVPFLIMFR EGLEAALIVS LIASYLKRTQ RGQWMGAVWV GVVVAAVLCL AIGIFINETT
     GEFPQKQQEL FEGIIAVVAV CILTYMVFWM RKVSKSVKVH LEGAIDNALN SGRGQGWALV
     AMVFFAVARE GLESVFFLLA AFQQDVGIGA PIGAILGLVC AILVGMAIYW GGVKLHLAKF
     FKWTSLFILF VAAGLAAGAI RAFHEAGLWN HFQDIAFDLT DVLSTHSLLG TFLEGMFGYQ
     EAPTVSEVSV YFIYLIPALI LFFLPPRSTA GSAIAAARKI NP