ID   EFEU_YERPS              Reviewed;         285 AA.
AC   Q66BP6;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Ferrous iron permease EfeU;
DE   AltName: Full=Fe(2+) ion permease EfeU;
DE   AltName: Full=Ferrous iron uptake protein;
GN   Name=efeU; OrderedLocusNames=YPTB1725;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Uptake of Fe(2+) ions across the membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a ferrous iron transporter composed of EfeU, EfeO and
CC       EfeB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC       9.A.10.1) family. {ECO:0000305}.
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DR   EMBL; BX936398; CAH20964.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q66BP6; -.
DR   SMR; Q66BP6; -.
DR   EnsemblBacteria; CAH20964; CAH20964; YPTB1725.
DR   KEGG; yps:YPTB1725; -.
DR   OMA; WYGTLLK; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   InterPro; IPR005217; FTR1-like.
DR   InterPro; IPR004923; FTR1/Fip1/EfeU.
DR   PANTHER; PTHR31632; PTHR31632; 1.
DR   Pfam; PF03239; FTR1; 1.
DR   TIGRFAMs; TIGR00145; TIGR00145; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..285
FT                   /note="Ferrous iron permease EfeU"
FT                   /id="PRO_0000277552"
FT   TOPO_DOM        1..4
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..38
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..72
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..121
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        143..150
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..182
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..247
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..285
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   285 AA;  31024 MW;  C85475A58F11E883 CRC64;
     MFSTFVPFLI MFREGLEAAL IVSLIASYLK RTQRGQWMGA VWVGVVVAAV LCLAIGIFIN
     ETTGEFPQKQ QELFEGIIAV VAVCILTYMV FWMRKVSKSV KVHLEGAIDN ALNSGRGQGW
     ALVAMVFFAV AREGLESVFF LLAAFQQDVG IGAPIGAILG LVCAILVGMA IYWGGVKLHL
     AKFFKWTSLF ILFVAAGLAA GAIRAFHEAG LWNHFQDIAF DLTDVLSTHS LLGTFLEGMF
     GYQEAPTVSE VSVYFIYLIP ALILFFLPPR STAGSAIAAA RKINP