ID   EFG1P_AJECN             Reviewed;         370 AA.
AC   A6RBE9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=rRNA-processing protein EFG1;
GN   Name=EFG1; ORFNames=HCAG_06287;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Involved in rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EFG1 family. {ECO:0000305}.
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DR   EMBL; CH476661; EDN10484.1; -; Genomic_DNA.
DR   RefSeq; XP_001538682.1; XM_001538632.1.
DR   AlphaFoldDB; A6RBE9; -.
DR   SMR; A6RBE9; -.
DR   STRING; 339724.A6RBE9; -.
DR   PRIDE; A6RBE9; -.
DR   EnsemblFungi; EDN10484; EDN10484; HCAG_06287.
DR   GeneID; 5445107; -.
DR   KEGG; aje:HCAG_06287; -.
DR   VEuPathDB; FungiDB:HCAG_06287; -.
DR   HOGENOM; CLU_066912_0_0_1; -.
DR   OMA; KCMEEKT; -.
DR   OrthoDB; 1514264at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR019310; Efg1.
DR   Pfam; PF10153; Efg1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; rRNA processing.
FT   CHAIN           1..370
FT                   /note="rRNA-processing protein EFG1"
FT                   /id="PRO_0000330257"
FT   REGION          1..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          132..189
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        10..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..242
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..354
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..370
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   370 AA;  42369 MW;  DEDDD0D28BB06D7A CRC64;
     MASSSFQKQG KRKDMADDSI SFETSKRHRG DYRNSREASP IVRDGQDDRR KYIDRREPGK
     QPSRPQIRDS NTFGGAQPGQ DDHAYAAGRS TSKPFRSRDL DLPSANELKN KIRDTKRLLK
     RGDHLPADVR IEKERALVGY ERDLEIVESR KNRAAMIKRY HFVRFLERKA ATRRLNKLLK
     QKKTLTESNP NLDKKELDFV EEQIYVTQVD LNYAIYSPLT EKYISLYPNQ RRDKKTPEPD
     PEDSNIIRNN SGEKPPLWYT VEQSMKDGTL ELLRDGKLGI GISGQKTSNN GPIAVLGRKN
     NETVSGSSVA TEGDSKQQGR KKDKEKQHDV KKSKEQEGSK NSGPRRRDVH MDDQNNEDGD
     DDSDGGFFEE