ID   EFG1P_COCIM             Reviewed;         309 AA.
AC   Q1E0G9; J3KCV2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=rRNA-processing protein EFG1;
GN   Name=EFG1; ORFNames=CIMG_03944;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EFG1 family. {ECO:0000305}.
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DR   EMBL; GG704916; EAS32920.3; -; Genomic_DNA.
DR   RefSeq; XP_001244503.1; XM_001244502.2.
DR   AlphaFoldDB; Q1E0G9; -.
DR   SMR; Q1E0G9; -.
DR   STRING; 246410.Q1E0G9; -.
DR   EnsemblFungi; EAS32920; EAS32920; CIMG_03944.
DR   GeneID; 4562814; -.
DR   KEGG; cim:CIMG_03944; -.
DR   VEuPathDB; FungiDB:CIMG_03944; -.
DR   InParanoid; Q1E0G9; -.
DR   OMA; KCMEEKT; -.
DR   OrthoDB; 1514264at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR019310; Efg1.
DR   Pfam; PF10153; Efg1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; rRNA processing.
FT   CHAIN           1..309
FT                   /note="rRNA-processing protein EFG1"
FT                   /id="PRO_0000330268"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          70..134
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        258..293
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..309
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  35705 MW;  4700CF599560C81C CRC64;
     MSLHEPEAQP SLKKRRRDSF SNADPKRVKR LHSGTQRLHY HDIGPSVNEL KTRIRDVKRL
     LAKRIDDLPA DVRVAKEREL AECQRDLEKA EVKKQRSKMI QKYHFVRFLE RKRATKELKR
     LKGQLHKLEN DDRLDPNARE NSIETLNRKI SASEIDLNYT IYSPLTEKYI SLYPNERRKQ
     QPMEPEESNV IRTNSGEKPP LWYTVKQSMA DGTLELLRDG KLGIGLSGEK KDSNNADVSL
     KSNTMSLLVH RKQKKPKSKI KVDGDEDAKR SSARSVQEGT RNENKRTSKE DVQGEDDDAE
     SESDGGFFE