ID   EFG1P_KLULA             Reviewed;         228 AA.
AC   Q6CXA6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=rRNA-processing protein EFG1;
GN   Name=EFG1; OrderedLocusNames=KLLA0A09911g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EFG1 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH03021.1; -; Genomic_DNA.
DR   RefSeq; XP_451433.1; XM_451433.1.
DR   AlphaFoldDB; Q6CXA6; -.
DR   SMR; Q6CXA6; -.
DR   STRING; 28985.XP_451433.1; -.
DR   EnsemblFungi; CAH03021; CAH03021; KLLA0_A09911g.
DR   GeneID; 2896384; -.
DR   KEGG; kla:KLLA0_A09911g; -.
DR   eggNOG; KOG4484; Eukaryota.
DR   HOGENOM; CLU_066912_2_0_1; -.
DR   InParanoid; Q6CXA6; -.
DR   OMA; HMIRFFE; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0030685; C:nucleolar preribosome; IEA:EnsemblFungi.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0071027; P:nuclear RNA surveillance; IEA:EnsemblFungi.
DR   GO; GO:0000321; P:re-entry into mitotic cell cycle after pheromone arrest; IEA:EnsemblFungi.
DR   InterPro; IPR019310; Efg1.
DR   Pfam; PF10153; Efg1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; rRNA processing.
FT   CHAIN           1..228
FT                   /note="rRNA-processing protein EFG1"
FT                   /id="PRO_0000330273"
FT   REGION          197..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          26..74
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        204..228
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   228 AA;  26511 MW;  2041E9183E17C45A CRC64;
     MSGKSKRPRQ RHDSSLQLAS VIGAGANKIK KQIRNVERLL QKRRDVLPDT VIVEKERMLE
     GLKFELKEAE LRQVGRKNAK KYHMVRFFER KKALRRYKQA SKKVIADPEN KRFQNELRDC
     TIDLCYVVNF PRLSKYIALY PTGSSDAKEL SEEVKKGLDS TDAKRTEFRN LVAKQLDEGT
     LPVSLSQILE GKRLNKDSTG VMLEEEQVEE EATEKQFNDE EEEDDFFE