3L22A_AUSLA
ID 3L22A_AUSLA Reviewed; 107 AA.
AC B2BRQ6;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Alpha-elapitoxin-Al2a;
DE Short=Alpha-EPTX-Al2a;
DE AltName: Full=Putative long neurotoxin;
DE Flags: Precursor;
OS Austrelaps labialis (Pygmy copperhead) (Denisonia superba).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Acanthophiinae; Austrelaps.
OX NCBI_TaxID=471292;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18307759; DOI=10.1186/1471-2148-8-70;
RA Doley R., Tram N.N.B., Reza M.A., Kini R.M.;
RT "Unusual accelerated rate of deletions and insertions in toxin genes in the
RT venom glands of the pygmy copperhead (Austrelaps labialis) from Kangaroo
RT island.";
RL BMC Evol. Biol. 8:70-70(2008).
CC -!- FUNCTION: Binds with high affinity to muscular (alpha-1/CHRNA1) and
CC neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and
CC inhibits acetylcholine from binding to the receptor, thereby impairing
CC neuromuscular and neuronal transmission.
CC {ECO:0000250|UniProtKB:P60615}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Long-chain
CC subfamily. Type II alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR EMBL; EU003086; ABX58152.1; -; mRNA.
DR AlphaFoldDB; B2BRQ6; -.
DR SMR; B2BRQ6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 3: Inferred from homology;
KW Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..107
FT /note="Alpha-elapitoxin-Al2a"
FT /id="PRO_0000420998"
FT DISULFID 24..41
FT /evidence="ECO:0000250"
FT DISULFID 34..62
FT /evidence="ECO:0000250"
FT DISULFID 47..51
FT /evidence="ECO:0000250"
FT DISULFID 66..77
FT /evidence="ECO:0000250"
FT DISULFID 78..83
FT /evidence="ECO:0000250"
SQ SEQUENCE 107 AA; 11935 MW; 9AE0374B650F98A7 CRC64;
MKTLLLTLVV VTIVCLDLGD SLRCYMGPKT PRTCPPGENL CFTKTWCDPR CSLLGKLVKL
GCAATCPIPK SYEDVTCCST DNCNRFPKWE RSRPRPRGLL SSIMDHP