ID   ADY4_YEAST              Reviewed;         493 AA.
AC   Q05955; D6VYM7;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Accumulates dyads protein 4;
GN   Name=ADY4; OrderedLocusNames=YLR227C; ORFNames=L8083.11;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=11470404; DOI=10.1016/s0960-9822(01)00274-3;
RA   Rabitsch K.P., Toth A., Galova M., Schleiffer A., Schaffner G., Aigner E.,
RA   Rupp C., Penkner A.M., Moreno-Borchart A.C., Primig M., Esposito R.E.,
RA   Klein F., Knop M., Nasmyth K.;
RT   "A screen for genes required for meiosis and spore formation based on
RT   whole-genome expression.";
RL   Curr. Biol. 11:1001-1009(2001).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND INTERACTION WITH
RP   CNM67; SPO21 AND NUD1.
RX   PubMed=12796288; DOI=10.1128/ec.2.3.431-445.2003;
RA   Nickas M.E., Schwartz C., Neiman A.M.;
RT   "Ady4p and Spo74p are components of the meiotic spindle pole body that
RT   promote growth of the prospore membrane in Saccharomyces cerevisiae.";
RL   Eukaryot. Cell 2:431-445(2003).
CC   -!- FUNCTION: Involved in the pathway that organizes the shaping and sizing
CC       of the prospore membrane (PSM) during sporulation. May be required to
CC       stabilize the outer plaque of the spindle pole body (SPB).
CC       {ECO:0000269|PubMed:12796288}.
CC   -!- SUBUNIT: Interacts with CNM67, SPO21/MPC70 and NUD1.
CC       {ECO:0000269|PubMed:12796288}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, spindle pole body {ECO:0000269|PubMed:12796288}. Note=Localizes
CC       to the meiotic outer plaque of the SPB, at the end of the meiotic
CC       spindles.
CC   -!- DEVELOPMENTAL STAGE: Meiosis-specific. {ECO:0000269|PubMed:12796288}.
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DR   EMBL; U19027; AAB67414.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09543.1; -; Genomic_DNA.
DR   PIR; S51450; S51450.
DR   RefSeq; NP_013328.1; NM_001182114.1.
DR   AlphaFoldDB; Q05955; -.
DR   BioGRID; 31494; 185.
DR   DIP; DIP-4786N; -.
DR   IntAct; Q05955; 6.
DR   STRING; 4932.YLR227C; -.
DR   PaxDb; Q05955; -.
DR   PRIDE; Q05955; -.
DR   EnsemblFungi; YLR227C_mRNA; YLR227C; YLR227C.
DR   GeneID; 850924; -.
DR   KEGG; sce:YLR227C; -.
DR   SGD; S000004217; ADY4.
DR   VEuPathDB; FungiDB:YLR227C; -.
DR   eggNOG; ENOG502S0MP; Eukaryota.
DR   HOGENOM; CLU_043424_0_0_1; -.
DR   OMA; FRWCLQF; -.
DR   BioCyc; YEAST:G3O-32341-MON; -.
DR   PRO; PR:Q05955; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q05955; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0035974; C:meiotic spindle pole body; IDA:SGD.
DR   GO; GO:0005198; F:structural molecule activity; IDA:SGD.
DR   GO; GO:0030437; P:ascospore formation; IMP:SGD.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Meiosis;
KW   Reference proteome; Sporulation.
FT   CHAIN           1..493
FT                   /note="Accumulates dyads protein 4"
FT                   /id="PRO_0000064462"
SQ   SEQUENCE   493 AA;  57833 MW;  33A6E36B76181927 CRC64;
     MNKDVDYQTF KKSLRKEFKK AVKTILNLQA YNGDLIRDFL ALYIPYHVVF YNLSIMKKGS
     PLRIQTNNLL KEALAKILNF NLAMGPKHII KIMKKDKADP ETMNKLKLVL YIKLFQGVFG
     HVDKNYNLAF QSFRWCLQFI AYSKRTRLFA SIADEQIGAF YELCELFISM LCCHCFLIDL
     KENEALVGNN LKNFIKRQNP NYSHGFDLNE ETKSLQWHWS LDEVDVIEAL YCVAFDAMDK
     ITLKFSKVNE NFVFSQFFQY CAEIEEMLAI LRGKIWECEC DVFGPRIGLL VDSNHMNETI
     QKNILSITFK LKNDPQIICC LNKILEGLLL SSGVQFKVIQ FFYVLKLYYM QDNEYTFEAS
     SEMDKLTIEC LCIIENIIDA CDNPDEVTDY QLPKVLLTAM EGKLLVAEKI SEDNDCSESL
     DDYHPRTYQF RHPRIIIDKM KTKLKQKLRF DSPKDPETDD HWIEYWKYCY QDNIGNLPDI
     LSRIYQTFTD PSN