AE7_ARATH
ID AE7_ARATH Reviewed; 157 AA.
AC Q9C9G6; F4HX83; Q84JZ3;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Protein AE7 {ECO:0000303|PubMed:21070412};
DE AltName: Full=AS1/2 enhancer 7 {ECO:0000303|PubMed:21070412};
DE AltName: Full=Asymmetric leaves 1/2 enhancer 7 {ECO:0000303|PubMed:21070412};
GN Name=AE7 {ECO:0000303|PubMed:21070412};
GN OrderedLocusNames=At1g68310 {ECO:0000312|Araport:AT1G68310};
GN ORFNames=T22E19.6 {ECO:0000312|EMBL:AAG52613.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
RP GLU-51.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=21070412; DOI=10.1111/j.1365-313x.2010.04326.x;
RA Yuan Z., Luo D., Li G., Yao X., Wang H., Zeng M., Huang H., Cui X.;
RT "Characterization of the AE7 gene in Arabidopsis suggests that normal cell
RT proliferation is essential for leaf polarity establishment.";
RL Plant J. 64:331-342(2010).
RN [7]
RP FUNCTION, MUTAGENESIS OF GLU-51, INTERACTION WITH CIA1; MMS19 AND NAR1,
RP SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=23104832; DOI=10.1105/tpc.112.102608;
RA Luo D., Bernard D.G., Balk J., Hai H., Cui X.;
RT "The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster
RT assembly pathway to maintain nuclear genome integrity in Arabidopsis.";
RL Plant Cell 24:4135-4148(2012).
CC -!- FUNCTION: Central member of the cytosolic iron-sulfur (Fe-S) protein
CC assembly (CIA) pathway (PubMed:23104832). Involved in leaf polarity
CC formation (PubMed:21070412). Promotes leaf adaxial identity
CC (PubMed:21070412). May play a role in the cell cycle progression and is
CC required for cell proliferation (PubMed:21070412).
CC {ECO:0000269|PubMed:21070412, ECO:0000269|PubMed:23104832}.
CC -!- SUBUNIT: Part of a complex formed of AE7, CIA1, MMS19 and NAR1.
CC Interacts with CIA1 and MMS19, but not with NAR1.
CC {ECO:0000269|PubMed:23104832}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23104832}. Cytoplasm
CC {ECO:0000269|PubMed:23104832}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C9G6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C9G6-2; Sequence=VSP_057802;
CC -!- TISSUE SPECIFICITY: Expressed in the embryo, shoot apical meristem,
CC leaf primordia, inflorescence and all floral organs.
CC {ECO:0000269|PubMed:21070412}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the globular-stage, heart-
CC stage and torpedo-stage embryos. {ECO:0000269|PubMed:21070412}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality when homozygous.
CC {ECO:0000269|PubMed:23104832}.
CC -!- SIMILARITY: Belongs to the MIP18 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52613.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC016447; AAG52613.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34779.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34780.1; -; Genomic_DNA.
DR EMBL; BT005787; AAO64190.1; -; mRNA.
DR EMBL; BT006073; AAP04058.1; -; mRNA.
DR EMBL; AK228380; BAF00318.1; -; mRNA.
DR EMBL; AK319096; BAH57211.1; -; mRNA.
DR PIR; G96706; G96706.
DR RefSeq; NP_001154457.1; NM_001160985.2. [Q9C9G6-1]
DR RefSeq; NP_176998.1; NM_105502.2. [Q9C9G6-2]
DR AlphaFoldDB; Q9C9G6; -.
DR SMR; Q9C9G6; -.
DR BioGRID; 28381; 1.
DR STRING; 3702.AT1G68310.1; -.
DR iPTMnet; Q9C9G6; -.
DR PaxDb; Q9C9G6; -.
DR PRIDE; Q9C9G6; -.
DR ProteomicsDB; 244726; -. [Q9C9G6-1]
DR EnsemblPlants; AT1G68310.1; AT1G68310.1; AT1G68310. [Q9C9G6-2]
DR EnsemblPlants; AT1G68310.2; AT1G68310.2; AT1G68310. [Q9C9G6-1]
DR GeneID; 843160; -.
DR Gramene; AT1G68310.1; AT1G68310.1; AT1G68310. [Q9C9G6-2]
DR Gramene; AT1G68310.2; AT1G68310.2; AT1G68310. [Q9C9G6-1]
DR KEGG; ath:AT1G68310; -.
DR Araport; AT1G68310; -.
DR TAIR; locus:2199362; AT1G68310.
DR eggNOG; KOG3381; Eukaryota.
DR HOGENOM; CLU_075876_3_0_1; -.
DR InParanoid; Q9C9G6; -.
DR OMA; NQCISAR; -.
DR OrthoDB; 1408004at2759; -.
DR PhylomeDB; Q9C9G6; -.
DR PRO; PR:Q9C9G6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9G6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0010209; F:vacuolar sorting signal binding; IDA:TAIR.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006259; P:DNA metabolic process; IMP:TAIR.
DR GO; GO:1990067; P:intrachromosomal DNA recombination; IMP:TAIR.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IMP:TAIR.
DR GO; GO:0009944; P:polarity specification of adaxial/abaxial axis; IMP:TAIR.
DR GO; GO:2001022; P:positive regulation of response to DNA damage stimulus; IMP:TAIR.
DR GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; IEA:InterPro.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:TAIR.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:TAIR.
DR Gene3D; 3.30.300.130; -; 1.
DR InterPro; IPR034904; FSCA_dom_sf.
DR InterPro; IPR039796; MIP18.
DR InterPro; IPR002744; MIP18-like.
DR PANTHER; PTHR12377; PTHR12377; 1.
DR Pfam; PF01883; FeS_assembly_P; 1.
DR SUPFAM; SSF117916; SSF117916; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome partition; Cytoplasm; Nucleus;
KW Reference proteome.
FT CHAIN 1..157
FT /note="Protein AE7"
FT /id="PRO_0000212696"
FT VAR_SEQ 43..46
FT /note="HIRD -> ILSSSN (in isoform 2)"
FT /id="VSP_057802"
FT MUTAGEN 51
FT /note="E->K: In ae7-1; leaf adaxial-abaxial polarity
FT defects, highly accumulated DNA damage and activation of
FT the DNA damage response."
FT /evidence="ECO:0000269|PubMed:21070412,
FT ECO:0000269|PubMed:23104832"
SQ SEQUENCE 157 AA; 17835 MW; 4A7F266515C01450 CRC64;
MVSGLINENP IIYPKKERRL RTDTSITDEL TPEPIDQLEI FDHIRDIKDP EHPNTLEDLR
VVTEDSVEVD DENSYVRVTF TPTVEHCSMA TVIGLCVRVK LLRSLPSRYK IDIRVAPGSH
ATEDALNKQL NDKERVAAAL ENPNLVEMVD ECLPSEE