3L22H_OPHHA
ID 3L22H_OPHHA Reviewed; 93 AA.
AC A8N285;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Long neurotoxin LNTX-2 homolog;
DE Flags: Precursor;
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=17616557; DOI=10.1096/fj.07-8658com;
RA Rajagopalan N., Pung Y.F., Zhu Y.Z., Wong P.T.H., Kumar P.P., Kini R.M.;
RT "Beta-cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king
RT cobra) venom with beta-blocker activity.";
RL FASEB J. 21:3685-3695(2007).
CC -!- FUNCTION: Binds with high affinity to muscular (alpha-1/CHRNA1) and
CC neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and
CC inhibits acetylcholine from binding to the receptor, thereby impairing
CC neuromuscular and neuronal transmission.
CC {ECO:0000250|UniProtKB:P60615}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Long-chain
CC subfamily. Type II alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR EMBL; DQ902574; ABK41954.1; -; mRNA.
DR AlphaFoldDB; A8N285; -.
DR SMR; A8N285; -.
DR TopDownProteomics; A8N285; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 3: Inferred from homology;
KW Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..21
FT CHAIN 22..93
FT /note="Long neurotoxin LNTX-2 homolog"
FT /id="PRO_0000318906"
FT DISULFID 24..42
FT /evidence="ECO:0000250"
FT DISULFID 35..63
FT /evidence="ECO:0000250"
FT DISULFID 48..52
FT /evidence="ECO:0000250"
FT DISULFID 67..78
FT /evidence="ECO:0000250"
FT DISULFID 79..84
FT /evidence="ECO:0000250"
SQ SEQUENCE 93 AA; 10244 MW; 86837ED70F501A43 CRC64;
MKTLLLTLVV VTIVCLDLGY TTKCYVTPDA TSQTCPDGEN ICYTKSWCDV FCSSRGKRID
LGCAATCPKV KPGVDIKCCS TDNCNPFTPW KRH