ID   AEDO_DICDI              Reviewed;         218 AA.
AC   Q556I2; Q86K19;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Probable 2-aminoethanethiol dioxygenase;
DE            EC=1.13.11.19;
DE   AltName: Full=Cysteamine dioxygenase;
GN   Name=ado-1; ORFNames=DDB_G0273031;
GN   and
GN   Name=ado-2; ORFNames=DDB_G0274043;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cysteamine + O2 = H(+) + hypotaurine; Xref=Rhea:RHEA:14409,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57853,
CC         ChEBI:CHEBI:58029; EC=1.13.11.19;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL70455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAL71153.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000011; EAL70455.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL71153.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_644380.1; XM_639288.1.
DR   RefSeq; XP_645033.1; XM_639941.1.
DR   AlphaFoldDB; Q556I2; -.
DR   SMR; Q556I2; -.
DR   STRING; 44689.DDB0217097; -.
DR   PaxDb; Q556I2; -.
DR   EnsemblProtists; EAL70455; EAL70455; DDB_G0274043.
DR   EnsemblProtists; EAL71153; EAL71153; DDB_G0273031.
DR   GeneID; 8618710; -.
DR   GeneID; 8619266; -.
DR   KEGG; ddi:DDB_G0273031; -.
DR   KEGG; ddi:DDB_G0274043; -.
DR   dictyBase; DDB_G0273031; -.
DR   dictyBase; DDB_G0274043; -.
DR   eggNOG; KOG4281; Eukaryota.
DR   InParanoid; Q556I2; -.
DR   Reactome; R-DDI-1614558; Degradation of cysteine and homocysteine.
DR   PRO; PR:Q556I2; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0047800; F:cysteamine dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR012864; PCO/ADO.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR22966; PTHR22966; 1.
DR   Pfam; PF07847; PCO_ADO; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   4: Predicted;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..218
FT                   /note="Probable 2-aminoethanethiol dioxygenase"
FT                   /id="PRO_0000353848"
SQ   SEQUENCE   218 AA;  24708 MW;  934BCB0A614BA865 CRC64;
     MTILKQLITK ANLILPSVDK KVATLDSLVS VFKEIKCKDL KIDKPLTLTK PIGNGKKVFY
     YPLVENEKFT LAIFAFPPNT CIPTHDHPQM TVLSKVLYGS ISCDSFDWID NTSNVKKQGK
     AIYTGTNILN SNDEKVKITL PNENNIHRFQ SGDEHCAVLD LLYPPYDSNF YRSCTYYRPT
     SVNGSIVDLM PYYPDFDCEG DSSNKELNDL HIELSKLK