ID   AEE22_ARATH             Reviewed;         535 AA.
AC   Q9C9G2;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Probable acyl-activating enzyme 22;
DE            EC=6.2.1.-;
GN   Name=AEE22; OrderedLocusNames=At1g68270; ORFNames=T22E19.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=12805634; DOI=10.1104/pp.103.020552;
RA   Shockey J.M., Fulda M.S., Browse J.;
RT   "Arabidopsis contains a large superfamily of acyl-activating enzymes.
RT   Phylogenetic and biochemical analysis reveals a new class of acyl-coenzyme
RT   a synthetases.";
RL   Plant Physiol. 132:1065-1076(2003).
CC   -!- FUNCTION: May act as an acid--thiol ligase that activates carboxylic
CC       acids by forming acyl-CoAs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AC016447; AAG52596.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE34775.1; -; Genomic_DNA.
DR   PIR; C96706; C96706.
DR   RefSeq; NP_176994.1; NM_105498.1.
DR   AlphaFoldDB; Q9C9G2; -.
DR   SMR; Q9C9G2; -.
DR   STRING; 3702.AT1G68270.1; -.
DR   PaxDb; Q9C9G2; -.
DR   PRIDE; Q9C9G2; -.
DR   EnsemblPlants; AT1G68270.1; AT1G68270.1; AT1G68270.
DR   GeneID; 843156; -.
DR   Gramene; AT1G68270.1; AT1G68270.1; AT1G68270.
DR   KEGG; ath:AT1G68270; -.
DR   Araport; AT1G68270; -.
DR   TAIR; locus:2199267; AT1G68270.
DR   eggNOG; KOG1176; Eukaryota.
DR   HOGENOM; CLU_000022_59_5_1; -.
DR   InParanoid; Q9C9G2; -.
DR   OMA; EMRCGSA; -.
DR   OrthoDB; 312083at2759; -.
DR   PhylomeDB; Q9C9G2; -.
DR   BioCyc; ARA:AT1G68270-MON; -.
DR   PRO; PR:Q9C9G2; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C9G2; differential.
DR   Genevisible; Q9C9G2; AT.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 2.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Ligase; Lipid metabolism; Reference proteome.
FT   CHAIN           1..535
FT                   /note="Probable acyl-activating enzyme 22"
FT                   /id="PRO_0000415732"
SQ   SEQUENCE   535 AA;  60209 MW;  D6A437EDD1E287C2 CRC64;
     MDNMELCEAN NVPLTPITFL KRASECYPNR TSIIYGQTRF TWPQTYDRCC RLAASLISLN
     IAKNDVVSVV APNTPAIYEM HFAVPMAGAV LNPINTRLDA TSITTILRHA QPKILFIHRN
     FEPLAREILH LLSCDDLQLN LLVIFIDEYN SAKRVSSEEL DYESLIQMGE PTSPLVENMF
     RIQNEQDPIS LNYTSGTTAD PKGVVISHRG AYLTSLGVII GWEMSTCPVY LWIFAYVSLQ
     WMDVYMGNSS ARGHQCVYEP RNPLDMSHRS GPVHLMTGGS PLPAALVKKV QRLGFQVLHV
     YGLTEATGPA LFCEWQDEWN RLTENQQMEL KARQGLGILS VAEVDVKYNE TQESVPHDGK
     TMGEIVMKGN NIMKGYLKNS KATFEAFKHG WLNTGDVGVI HPDGHIEIKD RSKDIIISGG
     ENISSVEVEN ILYKHPRVFE VAVVAMPHRV WGETPCAFIV LQKGETNKED DEYKFVAREK
     ELIDYCRENL PHFMCPRKVV FLEELPKNGN GKILKPNLRA ITKGLVAEDE ANVIS