EFH1_CANAL
ID EFH1_CANAL Reviewed; 720 AA.
AC Q59P39; A0A1D8PHR3;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Transcriptional regulator EFH1;
DE AltName: Full=EFG1 homolog 1;
GN Name=EFH1; Synonyms=PHD1; OrderedLocusNames=CAALFM_C206340WA;
GN ORFNames=CaO19.12953, CaO19.5498;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION.
RX PubMed=12798685; DOI=10.1016/s0022-2836(03)00505-9;
RA Tebarth B., Doedt T., Krishnamurthy S., Weide M., Monterola F.,
RA Dominguez A., Ernst J.F.;
RT "Adaptation of the Efg1p morphogenetic pathway in Candida albicans by
RT negative autoregulation and PKA-dependent repression of the EFG1 gene.";
RL J. Mol. Biol. 329:949-962(2003).
RN [5]
RP FUNCTION.
RX PubMed=15218092; DOI=10.1091/mbc.e03-11-0782;
RA Doedt T., Krishnamurthy S., Bockmuhl D.P., Tebarth B., Stempel C.,
RA Russell C.L., Brown A.J., Ernst J.F.;
RT "APSES proteins regulate morphogenesis and metabolism in Candida
RT albicans.";
RL Mol. Biol. Cell 15:3167-3180(2004).
RN [6]
RP INDUCTION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=18069889; DOI=10.1371/journal.ppat.0030184;
RA White S.J., Rosenbach A., Lephart P., Nguyen D., Benjamin A., Tzipori S.,
RA Whiteway M., Mecsas J., Kumamoto C.A.;
RT "Self-regulation of Candida albicans population size during GI
RT colonization.";
RL PLoS Pathog. 3:E184-E184(2007).
CC -!- FUNCTION: Transcription factor that regulates filamentous growth
CC through repression of EFG1. Regulates the level of colonizing fungi,
CC favoring commensalism as opposed to candidiasis.
CC {ECO:0000269|PubMed:12798685, ECO:0000269|PubMed:15218092,
CC ECO:0000269|PubMed:18069889}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00630}.
CC -!- DISRUPTION PHENOTYPE: Exhibits increased colonization of the murine
CC intestinal tract, a model of commensal colonization.
CC {ECO:0000269|PubMed:18069889}.
CC -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27642.1; -; Genomic_DNA.
DR RefSeq; XP_711489.1; XM_706397.1.
DR AlphaFoldDB; Q59P39; -.
DR SMR; Q59P39; -.
DR BioGRID; 1229991; 1.
DR STRING; 237561.Q59P39; -.
DR GeneID; 3646929; -.
DR KEGG; cal:CAALFM_C206340WA; -.
DR CGD; CAL0000182054; EFH1.
DR VEuPathDB; FungiDB:C2_06340W_A; -.
DR eggNOG; ENOG502QW2C; Eukaryota.
DR HOGENOM; CLU_428924_0_0_1; -.
DR InParanoid; Q59P39; -.
DR OMA; DENTNCY; -.
DR OrthoDB; 1332605at2759; -.
DR PRO; PR:Q59P39; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:CGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0051701; P:biological process involved in interaction with host; IMP:CGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0036166; P:phenotypic switching; IMP:CGD.
DR GO; GO:1900241; P:positive regulation of phenotypic switching; IMP:CGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0007124; P:pseudohyphal growth; IMP:CGD.
DR GO; GO:0045595; P:regulation of cell differentiation; IMP:CGD.
DR Gene3D; 3.10.260.10; -; 1.
DR InterPro; IPR029790; EFG1/Phd1/StuA.
DR InterPro; IPR036887; HTH_APSES_sf.
DR InterPro; IPR018004; KilA_N/APSES_HTH.
DR InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR PANTHER; PTHR47792; PTHR47792; 2.
DR SMART; SM01252; KilA-N; 1.
DR SUPFAM; SSF54616; SSF54616; 1.
DR PROSITE; PS51299; HTH_APSES; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..720
FT /note="Transcriptional regulator EFH1"
FT /id="PRO_0000426078"
FT DOMAIN 446..552
FT /note="HTH APSES-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT DNA_BIND 480..501
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..645
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 81374 MW; 69EDE69293F7EFE8 CRC64;
MNGIMTTSSH SNFYNQDLVG APSSSDHIPG PSSQDQPTNN NSPQHHHQHD QSQTTHQNHP
LNQPIHHHPT QQNQSESQQS RQSHHLQQQQ QQQQQQQQNQ HNQQNLASSS TSYEMPSIYQ
QFTGSYQQTR VPKNFLLENA NYYTLQPGFP LVQAADYYST PTTTSANDYQ NSTINSIISP
SFQMGSVSTP DTQNSSIRSK QQQQHSYQQQ QPQQLSQSQH QSQVPDIFYT QGGTIGGYVT
TKQQQKEFSR KTSGDQTLVP QTNSKLQQQI SETSYSQQQQ QQQSPPTPQK QQQQQHYQHQ
TTQPYGGTGF MLYSQTGGPS SSPVAGNISI PTTIATTGQP NSQFQFTYGS PQQGSSSKTN
QMYLYQRQQQ QQQQHQQPQS QQMSQISQLS QQIPPQGSSK NISINSTPTK SRASSITTRS
GRQSRSTSIS SFIPQPDYPE RVIRPKVATT RWDDENTNCY QVRARNILVS RREDTNYING
TKLLNVIGMT RGKRDGILKT EKIKNVVKVG SMNLKGVWIP FDRAYEIARN EGVDSLLYPL
FVKNIKQYFL TKGHKLKSED DEQEILEEGM TRQREEVRRE GRSNGVGDFH NEEEEEIVGI
QEDAGPNTAE NDVPGDDEEE EDDDDDDDDD EEEGEQDDEE EEDGSSTSMS SSKNSESKLL
ETRDVIKSIV EEGDSTTGNV SEVKYVHEYL ERSPQSTAIK EEDLYYGSSH NTPLTVHKTL
