EFH51_TRYCR
ID EFH51_TRYCR Reviewed; 208 AA.
AC P41048;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=EF-hand protein 5 variant 1;
DE Short=EFH5;
DE AltName: Full=Calmodulin-ubiquitin-associated protein CUB2.65;
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8381204; DOI=10.1016/0166-6851(93)90250-2;
RA Ajioka J., Swindle J.T.;
RT "The calmodulin-ubiquitin associated genes of Trypanosoma cruzi: their
RT identification and transcription.";
RL Mol. Biochem. Parasitol. 57:127-136(1993).
CC -!- DOMAIN: This protein has four EF-hand domains, two of which may be
CC functional calcium-binding sites.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L01583; AAA30171.1; -; Genomic_DNA.
DR PIR; A48567; A48567.
DR AlphaFoldDB; P41048; -.
DR SMR; P41048; -.
DR VEuPathDB; TriTrypDB:BCY84_04471; -.
DR VEuPathDB; TriTrypDB:C3747_46g17; -.
DR VEuPathDB; TriTrypDB:C4B63_138g28; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0110100; -.
DR VEuPathDB; TriTrypDB:TcCL_ESM07168; -.
DR VEuPathDB; TriTrypDB:TcCLB.506391.30; -.
DR VEuPathDB; TriTrypDB:TcCLB.507483.20; -.
DR VEuPathDB; TriTrypDB:TcG_06156; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_006560; -.
DR VEuPathDB; TriTrypDB:TcYC6_0037190; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium; Metal-binding; Repeat.
FT CHAIN 1..208
FT /note="EF-hand protein 5 variant 1"
FT /id="PRO_0000073836"
FT DOMAIN 64..98
FT /note="EF-hand 1"
FT /evidence="ECO:0000305"
FT DOMAIN 99..134
FT /note="EF-hand 2"
FT /evidence="ECO:0000305"
FT DOMAIN 135..170
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 171..206
FT /note="EF-hand 4"
FT /evidence="ECO:0000305"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 118
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 123
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 148
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 152
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 154
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
SQ SEQUENCE 208 AA; 23688 MW; 30B366D009C127C4 CRC64;
MQARGTVKVQ GDAKVDGKMS TGQHSHHQHL NSTQANATTT ALEYRAMNRP LYRGPISHNI
ISEMAEGFYV LSGGYKKLFI PSKDVYALMQ NVGMHLTEEE FHDALRVIGQ SEPQNADELS
FSDFLLLMTR EVDDTMADEL RSAFFHYDKY KTGYVTRKQF TELFATLGER STPEELEELL
AVAEVDETDD KIDYNRFVNE LTSRVNCM
