ID   EFH52_TRYCR             Reviewed;         208 AA.
AC   P41049;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=EF-hand protein 5 variant 2;
DE            Short=EFH5;
DE   AltName: Full=Calmodulin-ubiquitin-associated protein CUB2.8;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8381204; DOI=10.1016/0166-6851(93)90250-2;
RA   Ajioka J., Swindle J.T.;
RT   "The calmodulin-ubiquitin associated genes of Trypanosoma cruzi: their
RT   identification and transcription.";
RL   Mol. Biochem. Parasitol. 57:127-136(1993).
CC   -!- DOMAIN: This protein has four EF-hand domains, two of which may be
CC       functional calcium-binding sites.
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DR   EMBL; L01584; AAA30172.1; -; Genomic_DNA.
DR   AlphaFoldDB; P41049; -.
DR   SMR; P41049; -.
DR   VEuPathDB; TriTrypDB:BCY84_04471; -.
DR   VEuPathDB; TriTrypDB:C3747_16g220; -.
DR   VEuPathDB; TriTrypDB:C4B63_138g28; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0110100; -.
DR   VEuPathDB; TriTrypDB:TcCL_NonESM05353; -.
DR   VEuPathDB; TriTrypDB:TcCLB.506391.30; -.
DR   VEuPathDB; TriTrypDB:TcCLB.507483.20; -.
DR   VEuPathDB; TriTrypDB:TcG_06156; -.
DR   VEuPathDB; TriTrypDB:TCSYLVIO_006560; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0037190; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Calcium; Metal-binding; Repeat.
FT   CHAIN           1..208
FT                   /note="EF-hand protein 5 variant 2"
FT                   /id="PRO_0000073837"
FT   DOMAIN          64..98
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          99..134
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          135..170
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          171..206
FT                   /note="EF-hand 4"
FT                   /evidence="ECO:0000305"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         118
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         123
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         148
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         152
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         154
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   208 AA;  23671 MW;  15516948A9F567E3 CRC64;
     MQARGTVKVQ GDANVDGKMS TGQHPHHQHL NSTQANATTT ALEYRAMNRP LYRGPISHNI
     ISEMAEGFYV LSGGYKKLFI PSKDVYALMQ NVGMHLTEEE FHDALRVIGQ SEPQNADELS
     FSDFLLLMTR EVDDTMADEL RSAFFHYDKH KTGYVTRKQF TELFATLAER STPEELEELL
     AVAEVDETDD KIDYNRFVNE LTSRVNCM