ID   EFH5_LEITA              Reviewed;         186 AA.
AC   P41045;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=EF-hand protein 5;
DE            Short=EFH5;
OS   Leishmania tarentolae (Sauroleishmania tarentolae).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   lizard Leishmania.
OX   NCBI_TaxID=5689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=UC;
RA   Campbell D.L., Elgort M.G., Fleischmann J., Kurath U.;
RT   "A homologue of the T. brucel EFH5 gene in leishmania tarentolae.";
RL   Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SEQUENCE REVISION.
RA   Campbell D.L.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- MISCELLANEOUS: This protein has four EF-hand homolog domains, two of
CC       which may be functional calcium-binding sites.
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DR   EMBL; X68966; CAA48769.1; -; Genomic_DNA.
DR   PIR; S29547; S29547.
DR   AlphaFoldDB; P41045; -.
DR   SMR; P41045; -.
DR   VEuPathDB; TriTrypDB:LtaPh_0909300; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Calcium; Metal-binding; Repeat.
FT   CHAIN           1..186
FT                   /note="EF-hand protein 5"
FT                   /id="PRO_0000073834"
FT   DOMAIN          41..76
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          77..112
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          113..148
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          149..186
FT                   /note="EF-hand 4"
FT                   /evidence="ECO:0000305"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         98
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         126
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         130
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  20805 MW;  60BA2F4A93A9580E CRC64;
     MSRSKEVSPN LSQQKRGDVR SAGISGFSSP IYRGRLNHSA SAELQEGYRI LTGGQKANII
     SDKDLFKAIH SCGLHTSEEE VNDLLRVVHQ DERTLGLEFP EFMMLMTKGI DEASIAEMRR
     PFSVLDKAKT GVITKKQFTE LFVSSGEHSS AEELEELMLL AETSEELEVV DYNKLINELA
     ILLNKM