ID   EFH5_TRYBB              Reviewed;         192 AA.
AC   P25027;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=EF-hand protein 5;
DE            Short=EFH5;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=427;
RX   PubMed=8380221; DOI=10.1128/mcb.13.1.207-216.1993;
RA   Wong S., Morales T.H., Neigel J.E., Campbell D.A.;
RT   "Genomic and transcriptional linkage of the genes for calmodulin, EF-hand 5
RT   protein, and ubiquitin extension protein 52 in Trypanosoma brucei.";
RL   Mol. Cell. Biol. 13:207-216(1993).
RN   [2]
RP   SIMILARITY TO EF-HAND PROTEINS.
RX   PubMed=1603064; DOI=10.1007/bf00587583;
RA   Wong S., Kretsinger R.H., Campbell D.A.;
RT   "Identification of a new EF-hand superfamily member from Trypanosoma
RT   brucei.";
RL   Mol. Gen. Genet. 233:225-230(1992).
CC   -!- DEVELOPMENTAL STAGE: Present at similar levels in the mammalian
CC       bloodstream form and the insect procyclic form.
CC   -!- DOMAIN: This protein has four EF-hand domains, two of which may be
CC       functional calcium-binding sites.
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DR   EMBL; X56511; CAA39862.1; -; Genomic_DNA.
DR   PIR; B48111; B48111.
DR   AlphaFoldDB; P25027; -.
DR   SMR; P25027; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Metal-binding; Repeat.
FT   CHAIN           1..192
FT                   /note="EF-hand protein 5"
FT                   /id="PRO_0000073835"
FT   DOMAIN          46..80
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          81..118
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          119..154
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          155..190
FT                   /note="EF-hand 4"
FT                   /evidence="ECO:0000305"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         100
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         102
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         107
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         132
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         136
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   192 AA;  21723 MW;  ADADCACD02FE4C10 CRC64;
     MKDKAPVSSQ QDHFSRGGAV GGKPISDVRG TSRPFYRKPV SHNTIAELAE GFRVLSNGQK
     TISIPMKEVS ALMASVGLHL SDEEFHEVMR VFGQGEQTNT EELSFKDFLS LMMCEVDDTM
     LEEMRGAFLH YDKQKTGFVT KKQFTELFAT GGECSTPEEV EELLTIAEQD ETDDKIDYNR
     FINELIHRLN FM