ID   AEL1_ARATH              Reviewed;         154 AA.
AC   A8MR89;
DT   22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein AE7-like 1 {ECO:0000303|PubMed:23104832};
DE   AltName: Full=MIP18 family protein At3g50845 {ECO:0000305};
GN   Name=AEL1 {ECO:0000303|PubMed:23104832};
GN   OrderedLocusNames=At3g50845 {ECO:0000312|Araport:AT3G50845};
GN   ORFNames=F18B3 {ECO:0000312|EMBL:AL049862};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   FUNCTION, AND IDENTIFICATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=23104832; DOI=10.1105/tpc.112.102608;
RA   Luo D., Bernard D.G., Balk J., Hai H., Cui X.;
RT   "The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster
RT   assembly pathway to maintain nuclear genome integrity in Arabidopsis.";
RL   Plant Cell 24:4135-4148(2012).
CC   -!- FUNCTION: May play a role in chromosome segregation through
CC       establishment of sister chromatid cohesion (By similarity). Unable to
CC       complement ae7 mutants, and thus probably not involved in the cytosolic
CC       iron-sulfur assembly (CIA) pathway (PubMed:23104832).
CC       {ECO:0000250|UniProtKB:Q9D187, ECO:0000269|PubMed:23104832}.
CC   -!- SIMILARITY: Belongs to the MIP18 family. {ECO:0000305}.
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DR   EMBL; AL049862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002686; AEE78717.1; -; Genomic_DNA.
DR   RefSeq; NP_001078267.1; NM_001084798.1.
DR   AlphaFoldDB; A8MR89; -.
DR   SMR; A8MR89; -.
DR   STRING; 3702.AT3G50845.1; -.
DR   PaxDb; A8MR89; -.
DR   PRIDE; A8MR89; -.
DR   ProteomicsDB; 244770; -.
DR   EnsemblPlants; AT3G50845.1; AT3G50845.1; AT3G50845.
DR   GeneID; 5008077; -.
DR   Gramene; AT3G50845.1; AT3G50845.1; AT3G50845.
DR   KEGG; ath:AT3G50845; -.
DR   Araport; AT3G50845; -.
DR   TAIR; locus:4010713823; AT3G50845.
DR   eggNOG; KOG3381; Eukaryota.
DR   HOGENOM; CLU_075876_3_1_1; -.
DR   InParanoid; A8MR89; -.
DR   OMA; YISEGAH; -.
DR   OrthoDB; 1408004at2759; -.
DR   PhylomeDB; A8MR89; -.
DR   PRO; PR:A8MR89; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; A8MR89; baseline and differential.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; IEA:InterPro.
DR   Gene3D; 3.30.300.130; -; 1.
DR   InterPro; IPR034904; FSCA_dom_sf.
DR   InterPro; IPR039796; MIP18.
DR   InterPro; IPR002744; MIP18-like.
DR   PANTHER; PTHR12377; PTHR12377; 1.
DR   Pfam; PF01883; FeS_assembly_P; 1.
DR   SUPFAM; SSF117916; SSF117916; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..154
FT                   /note="Protein AE7-like 1"
FT                   /id="PRO_0000433515"
SQ   SEQUENCE   154 AA;  17645 MW;  0D73F3DAB780223C CRC64;
     MTLGLINANP VVQAKKEGLV RREDQYRDDG VDPLEIYDYV RDIRDPEHPY TLEQLRVVSE
     ESVTVDDKLD RILITFTPTI QHCSMANIIG LCLRAKLKEC LQLHYKVDIR VSPGSHADEV
     SVNKQLNDKE RVVAALENPN LRQLVDECIY SDEI