ID   EFHC2_BOVIN             Reviewed;         733 AA.
AC   A0A3Q1N1R0;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 1.
DT   03-AUG-2022, entry version 14.
DE   RecName: Full=EF-hand domain-containing family member C2;
GN   Name=EFHC2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000312|Proteomes:UP000009136};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
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DR   RefSeq; XP_002700247.1; XM_002700201.3.
DR   RefSeq; XP_015326002.1; XM_015470516.1.
DR   PDB; 7RRO; EM; 3.40 A; W/X/Y/Z=1-733.
DR   PDBsum; 7RRO; -.
DR   SMR; A0A3Q1N1R0; -.
DR   Ensembl; ENSBTAT00000082791.1; ENSBTAP00000063049.1; ENSBTAG00000053072.1.
DR   GeneID; 100336399; -.
DR   KEGG; bta:100336399; -.
DR   CTD; 80258; -.
DR   VEuPathDB; HostDB:ENSBTAG00000053072; -.
DR   VGNC; VGNC:106722; EFHC2.
DR   GeneTree; ENSGT00530000063528; -.
DR   OMA; SCVPDCT; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000053072; Expressed in oviduct epithelium and 53 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR   GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR   InterPro; IPR006602; DM10_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR   PANTHER; PTHR12086; PTHR12086; 1.
DR   Pfam; PF06565; DUF1126; 4.
DR   SMART; SM00676; DM10; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS51336; DM10; 3.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome; Repeat.
FT   CHAIN           1..733
FT                   /note="EF-hand domain-containing family member C2"
FT                   /id="PRO_0000456160"
FT   DOMAIN          61..168
FT                   /note="DM10 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          212..354
FT                   /note="DM10 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          416..523
FT                   /note="DM10 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
SQ   SEQUENCE   733 AA;  85454 MW;  F689F5AEF9C514AC CRC64;
     MGKEKFHKSQ HWGFCNNVRM LVGEDKPGIG GELLFGQKIK PKYSVFPKGM GTDSPSWVAF
     DKQVLSFDAY LEDEVPDKSQ ENYRIRRYKI YFYLEDDTVE VNEPVLQNSG LPQGIFIRRH
     RISLPPPNED QFYTVHHFNV NTDIVFYGRT FKVYDCDAFT KNFLTKIGVK LNPPGQCPED
     PYMKTRREKL DCMEPICPYE SFDTLKQFLE YDRKVLRFFC VWDDSGSVFG DRRELILHYF
     LSDDTIEIKE VLPHNSGRDA MSLFLQRRKL PKYGPPGVYQ PGQLTDQTVL NVYGGYSETR
     VYGFLLDKYQ LGKLDQEFYK DTDLSIGTTI NVWGRKVLLC DCDDFTKTYY RTKYGIENFT
     SIPCKAPSPP KIERKFPPYT GFGSEEDSLR SCIGLMPTPH QRNFKKFIEF DSYGNISNTL
     RFFAKLITHK CADVERMFVI SYFLSDDTIS VFEPIERNSG YTGGMFLKRV RVKKPGQEVF
     KSEFSEYIKA EELYVGAKVN VNGYLFFLVN ADEYTLNYME RNSDKFPLSS IELVIQKLKE
     EECKSRELKQ VFTAADCMHT KMVDFNTFRE IMMNLTVGKL TDQEVITIAR RYRVPEDPCP
     HRNVLVAQAH EQLKKNAFEN FERLIAMCVY EDREKKKVLP SKDIKRLCKS SRLPLNEDLL
     GSLLSGFEDS EKQINYESFF CALNWRVNPV PVLEVASYIK ERCEDEWLGM PSPIPVKYIY
     YLNLLKDVFG VDE