ID   EFHC2_CHICK             Reviewed;         746 AA.
AC   Q32TG3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=EF-hand domain-containing family member C2;
GN   Name=EFHC2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16112844; DOI=10.1016/j.eplepsyres.2005.07.003;
RA   Gu W., Sander T., Heils A., Lenzen K.P., Steinlein O.K.;
RT   "A new EF-hand containing gene EFHC2 on Xp11.4: tentative evidence for
RT   association with juvenile myoclonic epilepsy.";
RL   Epilepsy Res. 66:91-98(2005).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000250|UniProtKB:A0A3Q1N1R0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A0A3Q1N1R0}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY823388; AAX08043.1; -; mRNA.
DR   AlphaFoldDB; Q32TG3; -.
DR   SMR; Q32TG3; -.
DR   STRING; 9031.ENSGALP00000026102; -.
DR   PaxDb; Q32TG3; -.
DR   PRIDE; Q32TG3; -.
DR   VEuPathDB; HostDB:geneid_418559; -.
DR   eggNOG; KOG0043; Eukaryota.
DR   InParanoid; Q32TG3; -.
DR   PhylomeDB; Q32TG3; -.
DR   TreeFam; TF314504; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR   GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR   InterPro; IPR006602; DM10_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR   PANTHER; PTHR12086; PTHR12086; 1.
DR   Pfam; PF06565; DUF1126; 3.
DR   SMART; SM00676; DM10; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS51336; DM10; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT   CHAIN           1..746
FT                   /note="EF-hand domain-containing family member C2"
FT                   /id="PRO_0000251705"
FT   DOMAIN          75..182
FT                   /note="DM10 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          226..367
FT                   /note="DM10 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          429..536
FT                   /note="DM10 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          557..592
FT                   /note="EF-hand"
SQ   SEQUENCE   746 AA;  86661 MW;  FABB06C01E21DD8B CRC64;
     MALPLLPGFS LGRNVGKEKF HKSQHWGYCN NVAMLLAEDK PGIGGEPLPG QKLIPKSSVF
     PAELGCGAPA WLAFDKQVLS FDAYFEEEVP DKNQEPYRIR HCKIYFYLED DTIQVLEPQV
     KNSGIIQGTI VRRHRIPLPS PNEDQFYTID HFNINAEVIF YARRYKIIDC DQFTKHFLRK
     MGFKLNPPGN RPDDPYTKER QKILDSMNPL RPYERIDTLK QFLEHDGHVL RFYCVWDDPE
     SLFHDPRELV LHYYLSDDTI DIKEVIPVNS GRDVVPLFLR RDKLPKYAPT GLYQPGTITS
     RTVLNVFGNL VGNRGRYILD NRKTGAVHQE FYRDSDLKIG AVINVWGRQI MLCDCDEFTK
     DYYRTKYGIE DFTPVPYKAP PPPKAEKPIP PYTGFGSEED SLCSCMSLLP KPPQKDFKKF
     MEKDRCGLES NTLRFLAKLV TDSPIDKDRK FIICYFLMMP LYSVFEHSQR NTGIIGGKFL
     EKGRIKKPGQ ELFKSEPSEY FKAQDLFIGA RVCFHGHNFL LVDADEYTIN YMEKHANEFA
     VADTGFIFKK LKDIAEPRSR EIRQVFAAAD PQHTKVIEYD PFRNLIVSIT DGAFSEHEIM
     TLGRHYGEKE EYEIDHHFLL AKAQEQLKKN SFENFEQLST ILVYNDREKC GALPYETCRT
     ICKSFKLPLS DDLLQTILTM FEDDHKQVNY KKFVDAVNWR EHQIPSFHTI KLPPKNEDDW
     NGQPPFLPVK RIKYLPLLDD LFGKEE