ID   EFHC2_DANRE             Reviewed;         748 AA.
AC   Q32TF8; Q08CU1;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=EF-hand domain-containing family member C2;
GN   Name=efhc2; ORFNames=zgc:152706;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gu W., Steinlein O.K.;
RT   "The EFHC family.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000250|UniProtKB:A0A3Q1N1R0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A0A3Q1N1R0}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX08048.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAX08048.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR   EMBL; AY823393; AAX08048.1; ALT_SEQ; mRNA.
DR   EMBL; BC124091; AAI24092.1; -; mRNA.
DR   AlphaFoldDB; Q32TF8; -.
DR   SMR; Q32TF8; -.
DR   STRING; 7955.ENSDARP00000010992; -.
DR   PaxDb; Q32TF8; -.
DR   ZFIN; ZDB-GENE-031001-10; efhc2.
DR   eggNOG; KOG0043; Eukaryota.
DR   InParanoid; Q32TF8; -.
DR   PhylomeDB; Q32TF8; -.
DR   PRO; PR:Q32TF8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR   GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR   GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   GO; GO:1903251; P:multi-ciliated epithelial cell differentiation; IMP:ZFIN.
DR   GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR   GO; GO:0039010; P:specification of pronephric distal tubule identity; IMP:ZFIN.
DR   InterPro; IPR006602; DM10_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR   PANTHER; PTHR12086; PTHR12086; 1.
DR   Pfam; PF06565; DUF1126; 3.
DR   SMART; SM00676; DM10; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS51336; DM10; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT   CHAIN           1..748
FT                   /note="EF-hand domain-containing family member C2"
FT                   /id="PRO_0000251706"
FT   DOMAIN          75..182
FT                   /note="DM10 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          226..366
FT                   /note="DM10 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          428..535
FT                   /note="DM10 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT   DOMAIN          556..591
FT                   /note="EF-hand 1"
FT   DOMAIN          631..666
FT                   /note="EF-hand 2"
FT   CONFLICT        88
FT                   /note="A -> D (in Ref. 1; AAX08048)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        159
FT                   /note="L -> V (in Ref. 1; AAX08048)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="V -> I (in Ref. 1; AAX08048)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        203..205
FT                   /note="LEE -> AK (in Ref. 1; AAX08048)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        425
FT                   /note="R -> Q (in Ref. 1; AAX08048)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        560
FT                   /note="T -> K (in Ref. 1; AAX08048)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   748 AA;  85457 MW;  9B6C88FF54307AA3 CRC64;
     MALPMLPGNS VNRNLGKDKF HKSQHFDYSN GVAMMVGTEK PGIGGDLLLG QSARAKYSRF
     PKGEGSGAPA WLAFDKQVLC FDAYFNEAVP QRREEKYRVR KCKIYFYLED DTIQVVEPEF
     KNSGIPQGTL IRRHRIPLPA PKDDCFYNVH HFNINQEVLF YSRNFMITDC DPFTRNFLVK
     MGVRLNPPAS TPADPYTTLR QELEENMKPL RPYERLDTLK QFLEHDRQVL RFYCYWDDSE
     SMFGDPRELI LHYFLADDTM EMYEVVPPNS GRDTVPKFLH RGKLPKHAPI PKRQPGEITD
     RTVLNVFGPV GQGGPYILDS LKTGALEEEF YKDSDLTIGA VINVWGRRVL ICDCDYFTKE
     YYRSKYGIED FPSISYKASP PPKPAKQVPP YTGFGSEEDS LCSCQGLLPK PPQKDFKKLM
     EKDRRGLVSN VLRFVGKMLT DSPVDKERVF IICFYLTDDT IAVFEPPQRN SGVIGGKFLE
     RGRVKKPGQE LFKSEMSEYF TAQDLYVGAH LLLNSQPFQL VDADDFTFSY MEQHADEFPK
     ANIGTIISKV KSISEEQQKT VKQFFTMSDP SSTGSLPYES FRTLLADLDV ELSEHEIMTL
     GRVYSVRQQP EVNVGLMLAV AQDHLKKKNF EKFSEMIQAF THEDRDRCGQ LSSKEARIIC
     KAFRLPLSDD LLRALLEKFA GESEKIDYHA FLSGINWREN PVPAVLPEDT VKFDADWRGE
     APEPAVKTIN YSLLLEDVFG SATNINDS