ID   EFHD1_BOVIN             Reviewed;         236 AA.
AC   Q17QM6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=EF-hand domain-containing protein D1;
DE   AltName: Full=EF-hand domain-containing protein 1;
DE   AltName: Full=Swiprosin-2;
GN   Name=EFHD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a calcium sensor for mitochondrial flash (mitoflash)
CC       activation, an event characterized by stochastic bursts of superoxide
CC       production (By similarity). May play a role in neuronal differentiation
CC       (By similarity). {ECO:0000250|UniProtKB:Q9BUP0,
CC       ECO:0000250|UniProtKB:Q9D4J1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9D4J1}.
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DR   EMBL; BC118270; AAI18271.1; -; mRNA.
DR   RefSeq; NP_001069300.1; NM_001075832.1.
DR   AlphaFoldDB; Q17QM6; -.
DR   SMR; Q17QM6; -.
DR   STRING; 9913.ENSBTAP00000019429; -.
DR   PaxDb; Q17QM6; -.
DR   PeptideAtlas; Q17QM6; -.
DR   Ensembl; ENSBTAT00000019429; ENSBTAP00000019429; ENSBTAG00000014596.
DR   GeneID; 522462; -.
DR   KEGG; bta:522462; -.
DR   CTD; 80303; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014596; -.
DR   VGNC; VGNC:28352; EFHD1.
DR   eggNOG; KOG0041; Eukaryota.
DR   GeneTree; ENSGT00390000012058; -.
DR   HOGENOM; CLU_094429_0_0_1; -.
DR   InParanoid; Q17QM6; -.
DR   OMA; RQDINEG; -.
DR   OrthoDB; 1511376at2759; -.
DR   TreeFam; TF320736; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000014596; Expressed in trachea and 102 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0061891; F:calcium ion sensor activity; ISS:UniProtKB.
DR   GO; GO:1900069; P:regulation of cellular hyperosmotic salinity response; ISS:UniProtKB.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR040365; EFHD1/2.
DR   PANTHER; PTHR13025; PTHR13025; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat.
FT   CHAIN           1..236
FT                   /note="EF-hand domain-containing protein D1"
FT                   /id="PRO_0000287581"
FT   DOMAIN          87..122
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          123..158
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         100
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         104
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         111
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000305"
FT   BINDING         136
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         138
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         140
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         142
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
FT   BINDING         147
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   236 AA;  26540 MW;  62DBFF1D54086BCD CRC64;
     MASEELASKL QRRLQWEEGD SGLQPAPGAA PDPEPQPQPP AWAPTARADA ELSAQLNRRL
     DINEGAARPR RCKVFHPYSE FPEFSRRLIK DLESMFKLYD AGRDGFIDLM ELKLMMEKLG
     APQTHLGLKS MIKEVDEDFD GKLSFREFLL IFHKAAAGEL QEDSGLMALA KLSEIDVALE
     GVKGAKDFFE AKVQALSCAS KFEAELKAEQ DERKREEEKR KVRQAAFREL KAAFSA