ID   EFL3_CAEEL              Reviewed;         600 AA.
AC   Q20619;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 2.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Transcription factor efl-3 {ECO:0000305};
DE   AltName: Full=E2F-like family member 3 {ECO:0000303|PubMed:21596899};
GN   Name=efl-3 {ECO:0000312|WormBase:F49E12.6};
GN   ORFNames=F49E12.6 {ECO:0000312|WormBase:F49E12.6};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=21596899; DOI=10.1534/genetics.111.128421;
RA   Winn J., Carter M., Avery L., Cameron S.;
RT   "Hox and a newly identified E2F co-repress cell death in Caenorhabditis
RT   elegans.";
RL   Genetics 188:897-905(2011).
CC   -!- FUNCTION: Probable transcription factor which represses gene expression
CC       in a subset of ventral nerve cord neurons (PubMed:21596899). Involved
CC       in regulating programmed cell death and determining cell fate during
CC       development, acting in a partially redundant manner with lin-39 to
CC       repress the BH3 domain-encoding gene egl-1 in the VA and VB motor
CC       neurons (PubMed:21596899). {ECO:0000269|PubMed:21596899}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU003796}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryos, larvae and adults
CC       (PubMed:21596899). Expression begins in multiple cells in embryos,
CC       reaching a maximum in the L1-L2 larval stages (PubMed:21596899).
CC       Expressed in the ventral nerve cord VA and VB neurons, but not in the
CC       VC neurons (PubMed:21596899). {ECO:0000269|PubMed:21596899}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown on a ced-3 mutant
CC       background results in ectopic egl-1 expression in posterior ventral
CC       nerve cord neurons (PubMed:21596899). RNAi-mediated knockdown on a
CC       simultaneous lin-39; ced-3 mutant background results in ectopic egl-1
CC       expression in midbody and posterior ventral nerve cord neurons
CC       (PubMed:21596899). {ECO:0000269|PubMed:21596899}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284602; CAA91391.2; -; Genomic_DNA.
DR   PIR; T22451; T22451.
DR   RefSeq; NP_495771.2; NM_063370.5.
DR   AlphaFoldDB; Q20619; -.
DR   SMR; Q20619; -.
DR   STRING; 6239.F49E12.6; -.
DR   EPD; Q20619; -.
DR   PaxDb; Q20619; -.
DR   PeptideAtlas; Q20619; -.
DR   EnsemblMetazoa; F49E12.6.1; F49E12.6.1; WBGene00009899.
DR   GeneID; 174341; -.
DR   KEGG; cel:CELE_F49E12.6; -.
DR   UCSC; F49E12.6; c. elegans.
DR   CTD; 174341; -.
DR   WormBase; F49E12.6; CE37018; WBGene00009899; efl-3.
DR   eggNOG; KOG2578; Eukaryota.
DR   GeneTree; ENSGT00940000170769; -.
DR   HOGENOM; CLU_462503_0_0_1; -.
DR   InParanoid; Q20619; -.
DR   OMA; KSYYQWQ; -.
DR   OrthoDB; 727069at2759; -.
DR   PhylomeDB; Q20619; -.
DR   Reactome; R-CEL-6804116; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00009899; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12081; PTHR12081; 1.
DR   Pfam; PF02319; E2F_TDP; 2.
DR   SMART; SM01372; E2F_TDP; 2.
DR   SUPFAM; SSF46785; SSF46785; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..600
FT                   /note="Transcription factor efl-3"
FT                   /id="PRO_0000451763"
FT   DNA_BIND        95..164
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        253..343
FT                   /evidence="ECO:0000255"
FT   REGION          35..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   600 AA;  66938 MW;  AEE4D04BE552A76F CRC64;
     MTTIFGSSNA MFLNIEANKE NIPPGTEFKK ESFVLPEPRV NRTTDPDHEN LLPSPVPRPS
     PAMSQLSDAS FLSQDGGAVN TSADEADDDL EVTSRKEKSL GLLCQRFLIA INEETVGSST
     REVHLETVAR KMNVEKRRIY DIVNVMEALD AMQKTNKSYY QWQGLESLPK LMFDLQNEAV
     EEGLPERVLR VEQAMCSFTE LSSPRGKQGF KDIVGSFVSC TSTPTTPSTS FDSVTVKMEP
     AGLLEKRSRV DTRDRQGRNS LAQLCRRFLM VLLSNPKNIR KVSLDVASTV LIKDPETEGF
     EPPSRSRCRR LYDIANVLVA LGLIKKVHYL FGTKKIPLFV YCGPEPDQTG SFDVFQSVER
     LLSSSQNVPQ TPIIKAQTDK IVQQIAGFGK RTLSEQNLTK PSGNTPKIAK IKSAAVRSSP
     MYMENNLFMF AEVVTAEAAA EKMRYDAFAQ LSRTILGSVA SINSLNAPLT SSQHPMTSRL
     PPLPMAPLQL PKLPEIPKPQ AQKQFTFPAT SRPRFNFPDY TPVQSTIRPL VSQMTFPQES
     SQLHNLDVKP KHLMSNILGE SKKFKNNQNT FEHTTSSAFQ VVKKGETRPK KVFGEIQNLQ