ID   EFM5_CAEEL              Reviewed;         218 AA.
AC   Q5WRN3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Protein-lysine N-methyltransferase M142.8 {ECO:0000255|HAMAP-Rule:MF_03187};
DE            EC=2.1.1.- {ECO:0000255|HAMAP-Rule:MF_03187};
GN   ORFNames=M142.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that methylates elongation factor 1-alpha.
CC       {ECO:0000255|HAMAP-Rule:MF_03187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03187}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. EFM5 family. {ECO:0000255|HAMAP-Rule:MF_03187}.
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DR   EMBL; Z73428; CAH60777.1; -; Genomic_DNA.
DR   RefSeq; NP_001255091.1; NM_001268162.1.
DR   AlphaFoldDB; Q5WRN3; -.
DR   SMR; Q5WRN3; -.
DR   STRING; 6239.M142.8a; -.
DR   EPD; Q5WRN3; -.
DR   PaxDb; Q5WRN3; -.
DR   PeptideAtlas; Q5WRN3; -.
DR   EnsemblMetazoa; M142.8a.1; M142.8a.1; WBGene00043057.
DR   GeneID; 176524; -.
DR   KEGG; cel:CELE_M142.8; -.
DR   UCSC; M142.8; c. elegans.
DR   CTD; 176524; -.
DR   WormBase; M142.8a; CE37540; WBGene00043057; -.
DR   eggNOG; KOG3350; Eukaryota.
DR   GeneTree; ENSGT00390000016366; -.
DR   HOGENOM; CLU_074410_2_1_1; -.
DR   InParanoid; Q5WRN3; -.
DR   OMA; HKCNFRP; -.
DR   OrthoDB; 1272987at2759; -.
DR   PhylomeDB; Q5WRN3; -.
DR   Reactome; R-CEL-8876725; Protein methylation.
DR   PRO; PR:Q5WRN3; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00043057; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q5WRN3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0018022; P:peptidyl-lysine methylation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03187; Methyltr_EFM5; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR019369; Efm5/EEF1AKMT1.
DR   InterPro; IPR041370; Mlase_EEF1AKMT1/ZCCHC4.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR13200; PTHR13200; 1.
DR   Pfam; PF10237; N6-adenineMlase; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..218
FT                   /note="Protein-lysine N-methyltransferase M142.8"
FT                   /id="PRO_0000311299"
SQ   SEQUENCE   218 AA;  24660 MW;  CCF727BA8FEF46E4 CRC64;
     MSDTDDIPQL SADTLAALSM FQAEQQEKIE QLQSGIIEKI DEDWQLSQFW YDDETSRKLV
     AEGVAAALEG SEARPARIGC VSSPTLVKFF HETEEYKTGQ IQLTLFEFDD RFGLKFPTEF
     VHYDYKHPTD LPAELLAKFD VIIADPPFLA AECLIKTAHS IRLLGKSDVK VLLCTGAIME
     DYASRLMAMH RTSFEPRHAN NLANDFSCFA NYQTLTFC