ID   EFM5_DICDI              Reviewed;         211 AA.
AC   Q86A24; Q559E3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Protein-lysine N-methyltransferase DDB_G0272708 {ECO:0000255|HAMAP-Rule:MF_03187};
DE            EC=2.1.1.- {ECO:0000255|HAMAP-Rule:MF_03187};
GN   ORFNames=DDB_G0272708;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that methylates elongation factor 1-alpha.
CC       {ECO:0000255|HAMAP-Rule:MF_03187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03187}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. EFM5 family. {ECO:0000255|HAMAP-Rule:MF_03187}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000008; EAL70991.1; -; Genomic_DNA.
DR   RefSeq; XP_644873.1; XM_639781.1.
DR   AlphaFoldDB; Q86A24; -.
DR   SMR; Q86A24; -.
DR   STRING; 44689.DDB0168893; -.
DR   PaxDb; Q86A24; -.
DR   EnsemblProtists; EAL70991; EAL70991; DDB_G0272708.
DR   GeneID; 8618552; -.
DR   KEGG; ddi:DDB_G0272708; -.
DR   dictyBase; DDB_G0272708; -.
DR   eggNOG; KOG3350; Eukaryota.
DR   HOGENOM; CLU_074410_4_0_1; -.
DR   InParanoid; Q86A24; -.
DR   OMA; HKCNFRP; -.
DR   PhylomeDB; Q86A24; -.
DR   Reactome; R-DDI-8876725; Protein methylation.
DR   PRO; PR:Q86A24; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0018022; P:peptidyl-lysine methylation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03187; Methyltr_EFM5; 1.
DR   InterPro; IPR019369; Efm5/EEF1AKMT1.
DR   InterPro; IPR041370; Mlase_EEF1AKMT1/ZCCHC4.
DR   PANTHER; PTHR13200; PTHR13200; 1.
DR   Pfam; PF10237; N6-adenineMlase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..211
FT                   /note="Protein-lysine N-methyltransferase DDB_G0272708"
FT                   /id="PRO_0000328751"
SQ   SEQUENCE   211 AA;  24823 MW;  4F198A89E6AB8CF4 CRC64;
     MSDSSDDEIT LSKESLSALQ DFYKSREVEQ QDKFEISEDW QLSQFWYEEE TSKFVANVIE
     QETIGGNVVV CLSTPSIYKV LHKNNNLLLN NNLFEYDKRF DVYGEKFHFY DYNNPEDGIS
     EQLKGNVDYI CLDPPFLSEE CIEKVAKTIA LLRKPTTRLL LLTGRIQWNN IQKYLPEMMI
     CEFEPKHPRL QNDFFCCSNY HSKLLGLENK K