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AEN_PONAB
ID   AEN_PONAB               Reviewed;         325 AA.
AC   Q5REE2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Apoptosis-enhancing nuclease;
DE            EC=3.1.-.-;
DE   AltName: Full=Interferon-stimulated 20 kDa exonuclease-like 1;
GN   Name=AEN; Synonyms=ISG20L1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exonuclease with activity against single- and double-stranded
CC       DNA and RNA. Mediates p53-induced apoptosis. When induced by p53
CC       following DNA damage, digests double-stranded DNA to form single-
CC       stranded DNA and amplifies DNA damage signals, leading to enhancement
CC       of apoptosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Note=Localized predomintly in the nucleolus.
CC       Translocates from the nucleolus to the nucleoplasm upon apoptosis
CC       induction (By similarity). {ECO:0000250}.
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DR   EMBL; CR857587; CAH89865.1; -; mRNA.
DR   RefSeq; NP_001124869.1; NM_001131397.1.
DR   AlphaFoldDB; Q5REE2; -.
DR   SMR; Q5REE2; -.
DR   STRING; 9601.ENSPPYP00000007664; -.
DR   GeneID; 100171731; -.
DR   KEGG; pon:100171731; -.
DR   CTD; 64782; -.
DR   eggNOG; KOG2249; Eukaryota.
DR   InParanoid; Q5REE2; -.
DR   OrthoDB; 1562214at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0004527; F:exonuclease activity; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; DNA damage; Exonuclease; Hydrolase; Nuclease; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..325
FT                   /note="Apoptosis-enhancing nuclease"
FT                   /id="PRO_0000324090"
FT   DOMAIN          110..266
FT                   /note="Exonuclease"
FT   REGION          53..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           27..35
FT                   /note="Nucleolar localization signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           165..188
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        281..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  36408 MW;  A076EFADFF986EA2 CRC64;
     MVPREAPESA QCLCPSLTIP NAKDVLRKRH KRRSRQHQRF MARKALLQEQ GLLSMPPEPG
     SSPLPTPFGA VTATEDASSG KQCPRAGSGG APCSRRPAPG KASGPLPSKC VAIDCEMVGT
     GPRGRVSELA RCSIVSYHGD VLYDKYIRPE MPIVDYRTRW SGITRQHMCK AIPFQVAQKE
     ILKLLKGKVV VGHALHNDFQ ALKYVHPRSQ TRDTTYVPNF LSEPSLHIRA RVSLKDLALQ
     LLHKKIQVGQ HGHSSVEDAT TAMELYRLVE VQWEQQEARS LWTCPEDREP DSSTDMEQYM
     EDQYWPDDLA HGSRGGAREA QDRRN
 
 
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