ID   EFP_BACFR               Reviewed;         188 AA.
AC   P70889; Q64Z41;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Elongation factor P;
DE            Short=EF-P;
GN   Name=efp; OrderedLocusNames=BF0486;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BF1;
RX   PubMed=9648740; DOI=10.1007/s004380050742;
RA   Abratt V.R., Mbewe M., Woods D.R.;
RT   "Cloning of an EF-P homologue from Bacteroides fragilis that increases B.
RT   fragilis glutamine synthetase activity in Escherichia coli.";
RL   Mol. Gen. Genet. 258:363-372(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: Involved in peptide bond synthesis. Stimulates efficient
CC       translation and peptide-bond synthesis on native or reconstituted 70S
CC       ribosomes in vitro. Probably functions indirectly by altering the
CC       affinity of the ribosome for aminoacyl-tRNA, thus increasing their
CC       reactivity as acceptors for peptidyl transferase (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein biosynthesis; polypeptide chain elongation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the elongation factor P family. {ECO:0000305}.
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DR   EMBL; U75509; AAC26328.1; -; Genomic_DNA.
DR   EMBL; AP006841; BAD47235.1; -; Genomic_DNA.
DR   RefSeq; WP_005784338.1; NZ_UYXF01000019.1.
DR   RefSeq; YP_097769.1; NC_006347.1.
DR   AlphaFoldDB; P70889; -.
DR   SMR; P70889; -.
DR   STRING; 295405.BF0486; -.
DR   EnsemblBacteria; BAD47235; BAD47235; BF0486.
DR   GeneID; 66330465; -.
DR   KEGG; bfr:BF0486; -.
DR   PATRIC; fig|295405.11.peg.502; -.
DR   HOGENOM; CLU_074944_0_1_10; -.
DR   OMA; WSVVEFQ; -.
DR   UniPathway; UPA00345; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04470; S1_EF-P_repeat_1; 1.
DR   CDD; cd05794; S1_EF-P_repeat_2; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.140; -; 2.
DR   HAMAP; MF_00141; EF_P; 1.
DR   InterPro; IPR015365; Elong-fact-P_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR020599; Transl_elong_fac_P/YeiP.
DR   InterPro; IPR013185; Transl_elong_KOW-like.
DR   InterPro; IPR001059; Transl_elong_P/YeiP_cen.
DR   InterPro; IPR013852; Transl_elong_P/YeiP_CS.
DR   InterPro; IPR011768; Transl_elongation_fac_P.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR30053; PTHR30053; 1.
DR   Pfam; PF01132; EFP; 1.
DR   Pfam; PF08207; EFP_N; 1.
DR   Pfam; PF09285; Elong-fact-P_C; 1.
DR   PIRSF; PIRSF005901; EF-P; 1.
DR   SMART; SM01185; EFP; 1.
DR   SMART; SM00841; Elong-fact-P_C; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF50249; SSF50249; 2.
DR   TIGRFAMs; TIGR00038; efp; 1.
DR   PROSITE; PS01275; EFP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Elongation factor; Protein biosynthesis.
FT   CHAIN           1..188
FT                   /note="Elongation factor P"
FT                   /id="PRO_0000094195"
FT   CONFLICT        20..22
FT                   /note="Missing (in Ref. 1; AAC26328)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   188 AA;  21225 MW;  14374B7C0C92F9A6 CRC64;
     MINAQDIKNG TCIRMDGKLY FCIEFLHVKP GKGNTFMRTK LKDVVSGYVL ERRFNIGEKL
     EDVRVERRPY QYLYKEGEDY IFMNQETFDQ HPIAHDLING VDFLLEGAVV EVVSDASTET
     VLYADMPIKV QMKVTYTEPG LKGDTATNTL KPATVESGAT VRVPLFISEG ETIEIDTRDG
     SYVGRVKA