ID   AEQL1_NEMVE             Reviewed;          88 AA.
AC   A7RFL3;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 2.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Protein Aeq5-like1 {ECO:0000303|PubMed:33060291};
DE   Flags: Precursor;
GN   ORFNames=v1g237880 {ECO:0000312|EMBL:EDO49621.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1] {ECO:0000312|EMBL:EDO49621.1, ECO:0000312|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000312|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-67, IDENTIFICATION BY
RP   MASS SPECTROMETRY, AND TISSUE SPECIFICITY.
RX   PubMed=33060291; DOI=10.1073/pnas.2011120117;
RA   Sachkova M.Y., Landau M., Surm J.M., Macrander J., Singer S.A.,
RA   Reitzel A.M., Moran Y.;
RT   "Toxin-like neuropeptides in the sea anemone Nematostella unravel
RT   recruitment from the nervous system to venom.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:27481-27492(2020).
CC   -!- FUNCTION: Probable neuropeptide. {ECO:0000305|PubMed:33060291}.
CC   -!- TISSUE SPECIFICITY: Is expressed in the ectodermal cells of gastrulae
CC       and planulae. Is also noticeable in the endoderm in late planulae. In
CC       the primary polyps, is expressed in both ectoderm (sensory neurons) and
CC       endoderm (ganglions). Is not expressed in nematocytes.
CC       {ECO:0000269|PubMed:33060291}.
CC   -!- DEVELOPMENTAL STAGE: Is strongly and equally detected in planulae, in
CC       primary polyps (9d), and in both adult females and males (at protein
CC       level) (PubMed:33060291). Transcripts are expressed early in
CC       development in ectodermal cells of the gastrula, then increases in
CC       early planula and by the late planula spreads in expression to
CC       endodermal cells. In primary polyps, they are expressed in ectodermal
CC       sensory cells and multiple endodermal ganglion cells that send their
CC       processes in different directions all around the body
CC       (PubMed:33060291). {ECO:0000269|PubMed:33060291}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDO49621.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DS469508; EDO49621.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001641684.1; XM_001641634.1.
DR   SMR; A7RFL3; -.
DR   EnsemblMetazoa; EDO49621; EDO49621; NEMVEDRAFT_v1g237880.
DR   HOGENOM; CLU_1724469_0_0_1; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neuropeptide;
KW   Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..88
FT                   /note="Protein Aeq5-like1"
FT                   /evidence="ECO:0000305|PubMed:33060291"
FT                   /id="PRO_0000453918"
FT   DISULFID        29..68
FT                   /evidence="ECO:0000250|UniProtKB:Q3C258"
FT   DISULFID        33..64
FT                   /evidence="ECO:0000250|UniProtKB:Q3C258"
FT   DISULFID        40..56
FT                   /evidence="ECO:0000250|UniProtKB:Q3C258"
FT   DISULFID        47..53
FT                   /evidence="ECO:0000250|UniProtKB:Q3C258"
SQ   SEQUENCE   88 AA;  10354 MW;  F9275B436005D274 CRC64;
     MKSVIAVLVL SLVLVNFTQA AKDDRWKACR MKCYTESKLC MNNDSKCFDS QSCNSCIQQV
     YSPCFNRCQE MLRRREAFKR MFAFDEEN